diffuse idiopathic skeletal hyperostosis: This syndrome is characterized by the association of ankylosing vertebral hyperostosis with hyperkeratosis of the soles and palms.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
430 |
4. Check minimum number of eventsNone |
430 |
5. Include endpointsNone |
430 |
6. Filter based on genotype QC (FinnGen only) |
412 |
Control definitions (FinnGen only)
Control exclude
M13_DORSOPATHY
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M48
Name in latin
Hyperostosis ancylopoetica
Similar endpoints
↥List of similar endpoints to
Ankylosing hyperostosis [Forestier]
based on the number of shared cases.
Similar with more cases:
- Spondylopathies
- Dorsopathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3079 | 1249 | 1805 |
| Only index persons | 2836 | 1179 | 1657 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.05 |
| Only index persons | 0.05 | 0.04 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 58.00 | 58.94 | 57.26 |
| Only index persons | 57.53 | 58.39 | 56.92 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 412 | 167 | 245 |
| Unadjusted period prevalence (%) | 0.10 | 0.07 | 0.12 |
| Median age at first event (years) | 57.71 | 56.78 | 58.35 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_FORESTIER and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_FORESTIER | 1.208 [1.03, 1.42] | 0.021 |
| Birth year | 0.99 [0.98, 1.0] | 0.023 |
During the follow-up period (1.1.1998 — 31.12.2019), 210 out of 1048 females with M13_FORESTIER died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_FORESTIER | 1.194 [1.04, 1.37] | 0.012 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 338 out of 1527 males with M13_FORESTIER died.
Mortality risk
Mortality risk for people of age
years, who have M13_FORESTIER.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.069% | 0.213% |
| 5 | 0.511% | 1.204% |
| 10 | 1.405% | 3.308% |
| 15 | 2.672% | 6.12% |
| 20 | 4.768% | 10.485% |
Relationships between endpoints
↥Index endpoint: M13_FORESTIER – Ankylosing hyperostosis [Forestier]
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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