No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
143 |
4. Check minimum number of eventsNone |
143 |
5. Include endpointsNone |
143 |
6. Filter based on genotype QC (FinnGen only) |
139 |
Control definitions (FinnGen only)
Control exclude
M13_DORSOPATHY
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M48
Name in latin
Fractura vertebrae ex fatigatione
Similar endpoints
↥List of similar endpoints to
Fatigue fracture of vertebra
based on the number of shared cases.
Similar with more cases:
- Spondylopathies
- Dorsopathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1686 | 892 | 789 |
| Only index persons | 1561 | 823 | 738 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.03 | 0.02 |
| Only index persons | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 40.97 | 61.05 | 18.09 |
| Only index persons | 40.52 | 60.94 | 17.75 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 139 | 87 | 52 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | 63.09 | 62.70 | 63.75 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint M13_FATIGFRACT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_FATIGFRACT | 1.518 [1.15, 2.0] | 0.003 |
| Birth year | 0.996 [0.99, 1.0] | 0.403 |
During the follow-up period (1.1.1998 — 31.12.2019), 179 out of 579 females with M13_FATIGFRACT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_FATIGFRACT | 1.865 [1.31, 2.66] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 109 out of 387 males with M13_FATIGFRACT died.
Mortality risk
Mortality risk for people of age
years, who have M13_FATIGFRACT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.183% | 0.329% |
| 5 | 0.973% | 1.964% |
| 10 | 2.401% | 4.885% |
| 15 | 4.479% | 8.956% |
| 20 | 7.785% | 15.13% |
Relationships between endpoints
↥Index endpoint: M13_FATIGFRACT – Fatigue fracture of vertebra
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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