No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
16669 |
4. Check minimum number of eventsNone |
16669 |
5. Include endpointsNone |
16669 |
6. Filter based on genotype QC (FinnGen only) |
16143 |
Control definitions (FinnGen only)
Control exclude
M13_DORSOPATHY
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M50-M54
Name in latin
Morbositates discorum intervertebralium cervicalium
Similar endpoints
↥List of similar endpoints to
Cervical disc disorders
based on the number of shared cases.
Similar with more cases:
- Dorsopathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 122021 | 59556 | 61740 |
| Only index persons | 110026 | 55313 | 54713 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.71 | 1.71 | 1.73 |
| Only index persons | 2.06 | 2.03 | 2.09 |
| Median age at first event (years) | |||
| Whole population | 49.00 | 49.82 | 48.15 |
| Only index persons | 48.25 | 49.17 | 47.32 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 16143 | 8630 | 7513 |
| Unadjusted period prevalence (%) | 3.57 | 3.39 | 3.77 |
| Median age at first event (years) | 48.97 | 48.24 | 49.81 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_CERVICDISC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_CERVICDISC | 1.004 [0.91, 1.11] | 0.943 |
| Birth year | 0.996 [0.99, 1.0] | 0.39 |
During the follow-up period (1.1.1998 — 31.12.2019), 2418 out of 31738 females with M13_CERVICDISC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_CERVICDISC | 0.978 [0.89, 1.07] | 0.622 |
| Birth year | 0.987 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 3257 out of 28407 males with M13_CERVICDISC died.
Mortality risk
Mortality risk for people of age
years, who have M13_CERVICDISC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.082% | 0.179% |
| 5 | 0.528% | 1.15% |
| 10 | 1.382% | 2.739% |
| 15 | 2.945% | 5.252% |
| 20 | 5.211% | 9.019% |
Relationships between endpoints
↥Index endpoint: M13_CERVICDISC – Cervical disc disorders
GWS hits: 11
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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