No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
102142 |
4. Check minimum number of eventsNone |
102142 |
5. Include endpoints |
102974 |
6. Filter based on genotype QC (FinnGen only) |
99107 |
Control definitions (FinnGen only)
Control exclude
M13_DORSOPATHY
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other dorsopathies, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Dorsopathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 842235 | 468842 | 368433 |
| Only index persons | 795603 | 447324 | 348279 |
| Unadjusted period prevalence (%) | |||
| Whole population | 12.01 | 13.43 | 10.29 |
| Only index persons | 15.07 | 16.44 | 13.30 |
| Median age at first event (years) | |||
| Whole population | 50.13 | 51.33 | 48.72 |
| Only index persons | 49.50 | 50.63 | 48.05 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 99107 | 60573 | 38534 |
| Unadjusted period prevalence (%) | 22.06 | 23.79 | 19.35 |
| Median age at first event (years) | 51.29 | 49.72 | 53.76 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_DORSOPATHYOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_DORSOPATHYOTH | 1.193 [1.1, 1.3] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.025 |
During the follow-up period (1.1.1998 — 31.12.2019), 53819 out of 393955 females with M13_DORSOPATHYOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_DORSOPATHYOTH | 1.22 [1.12, 1.33] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 45669 out of 309610 males with M13_DORSOPATHYOTH died.
Mortality risk
Mortality risk for people of age
years, who have M13_DORSOPATHYOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.083% | 0.191% |
| 5 | 0.55% | 1.369% |
| 10 | 1.414% | 3.368% |
| 15 | 2.645% | 6.16% |
| 20 | 4.588% | 10.609% |
Relationships between endpoints
↥Index endpoint: M13_DORSOPATHYOTH – Other dorsopathies, not elsewhere classified
GWS hits: 32
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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