No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1290 |
4. Check minimum number of eventsNone |
1290 |
5. Include endpointsNone |
1290 |
6. Filter based on genotype QC (FinnGen only) |
1240 |
Control definitions (FinnGen only)
Control exclude
M13_DORSOPATHY
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other specified/unspecified dorsopathies
based on the number of shared cases.
Similar with more cases:
- Other dorsopathies, not elsewhere classified
- Dorsopathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 12158 | 7344 | 4708 |
| Only index persons | 9530 | 5830 | 3700 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.18 | 0.21 | 0.13 |
| Only index persons | 0.19 | 0.21 | 0.14 |
| Median age at first event (years) | |||
| Whole population | 52.23 | 53.59 | 49.84 |
| Only index persons | 48.02 | 49.53 | 45.65 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1240 | 805 | 435 |
| Unadjusted period prevalence (%) | 0.28 | 0.32 | 0.22 |
| Median age at first event (years) | 48.68 | 47.61 | 50.66 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_DORSOPATHYNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_DORSOPATHYNAS | 1.224 [1.09, 1.38] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.154 |
During the follow-up period (1.1.1998 — 31.12.2019), 636 out of 3739 females with M13_DORSOPATHYNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_DORSOPATHYNAS | 1.185 [1.03, 1.37] | 0.021 |
| Birth year | 0.988 [0.98, 1.0] | 0.012 |
During the follow-up period (1.1.1998 — 31.12.2019), 406 out of 2279 males with M13_DORSOPATHYNAS died.
Mortality risk
Mortality risk for people of age
years, who have M13_DORSOPATHYNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.1% | 0.25% |
| 5 | 0.652% | 1.216% |
| 10 | 1.647% | 3.198% |
| 15 | 3.158% | 6.424% |
| 20 | 5.584% | 10.908% |
Relationships between endpoints
↥Index endpoint: M13_DORSOPATHYNAS – Other specified/unspecified dorsopathies
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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