No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
1031 |
4. Check minimum number of eventsNone |
1031 |
5. Include endpointsNone |
1031 |
6. Filter based on genotype QC (FinnGen only) |
999 |
Control definitions (FinnGen only)
Control exclude
M13_DORSOPATHY
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M53
Name in latin
Instabilitates dorsi
Similar endpoints
↥List of similar endpoints to
Spinal instabilities
based on the number of shared cases.
Similar with more cases:
- Other dorsopathies, not elsewhere classified
- Dorsopathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5536 | 3333 | 2184 |
| Only index persons | 5425 | 3281 | 2144 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.10 | 0.06 |
| Only index persons | 0.11 | 0.12 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 47.96 | 49.06 | 46.26 |
| Only index persons | 47.85 | 48.96 | 46.14 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 999 | 654 | 345 |
| Unadjusted period prevalence (%) | 0.23 | 0.26 | 0.17 |
| Median age at first event (years) | 50.94 | 50.75 | 51.31 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_SPININSTAB and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SPININSTAB | 0.97 [0.83, 1.14] | 0.708 |
| Birth year | 0.996 [0.99, 1.01] | 0.381 |
During the follow-up period (1.1.1998 — 31.12.2019), 197 out of 3121 females with M13_SPININSTAB died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SPININSTAB | 0.857 [0.72, 1.02] | 0.087 |
| Birth year | 0.987 [0.98, 1.0] | 0.02 |
During the follow-up period (1.1.1998 — 31.12.2019), 168 out of 2051 males with M13_SPININSTAB died.
Mortality risk
Mortality risk for people of age
years, who have M13_SPININSTAB.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.097% | 0.213% |
| 5 | 0.555% | 1.074% |
| 10 | 1.28% | 2.521% |
| 15 | 2.579% | 4.811% |
| 20 | 4.848% | 8.039% |
Relationships between endpoints
↥Index endpoint: M13_SPININSTAB – Spinal instabilities
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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