Cervicobrachial syndrome

M13_CERVICOBRACHSDR

brachial plexus neuritis: An inflammatory process affecting the brachial plexus. It results in severe pain in the upper extremity and shoulder, upper arm weakness and loss of sensation in the upper arm.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M53.1
  • Hospital discharge: ICD-9 7233
  • Hospital discharge: ICD-8 7282
  • Cause of death: ICD-10 M53.1
  • Cause of death: ICD-9 7233
  • Cause of death: ICD-8 7282

2 out of 7 registries used, show all original rules.

9571

4. Check minimum number of events

None

9571

5. Include endpoints

None

9571

6. Filter based on genotype QC (FinnGen only)

9185

Control definitions (FinnGen only)

Control exclude M13_DORSOPATHY

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M53
Name in latin Syndroma cervicobrachiale

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 72250 45144 26648
Only index persons 66877 42653 24224
Unadjusted period prevalence (%)
Whole population 1.09 1.29 0.74
Only index persons 1.34 1.57 0.92
Median age at first event (years)
Whole population 51.01 50.95 51.16
Only index persons 50.46 50.42 50.54

-FinnGen-

Key figures

All Female Male
Number of individuals 9185 6232 2953
Unadjusted period prevalence (%) 2.14 2.45 1.48
Median age at first event (years) 50.90 49.93 52.94

-FinRegistry-

Age distribution of first events

01020304050607080900k2k4k6k8k10k12k14k16k18k20k22kAgeIndividuals

-FinnGen-

Age distribution of first events

020304050607080900.0k0.2k0.4k0.6k0.8k1.0k1.2k1.4k1.6k1.8k2.0k2.2k2.4k2.6k2.8kAgeIndividuals

-FinRegistry-

Year distribution of first events

1970197519801985199019952000200520102015202020220k2k4k6k8k10k12k14kYearIndividuals

-FinnGen-

Year distribution of first events

1970197519801985199019952000200520102015202020230.0k0.2k0.4k0.6k0.8k1.0k1.2k1.4k1.6k1.8k2.0kYearIndividuals

-FinRegistry-

Cumulative Incidence Function

01020304050607080901000.00.51.01.52.02.53.03.54.04.55.0AgeProbability of first incidence (%)

-FinnGen-

Cumulative Incidence Function

01020304050607080901000.00.51.01.52.02.53.03.54.04.55.05.56.06.57.0AgeProbability of first incidence (%)

Mortality – FinRegistry

Association

Association between endpoint M13_CERVICOBRACHSDR and mortality.

Females

Parameter HR [95% CI] p-value
M13_CERVICOBRACHSDR 0.903 [0.81, 1.0] 0.06
Birth year 0.994 [0.99, 1.0] 0.177

During the follow-up period (1.1.1998 — 31.12.2019), 2228 out of 33570 females with M13_CERVICOBRACHSDR died.

Males

Parameter HR [95% CI] p-value
M13_CERVICOBRACHSDR 0.938 [0.85, 1.03] 0.188
Birth year 0.991 [0.98, 1.0] 0.054

During the follow-up period (1.1.1998 — 31.12.2019), 2127 out of 19733 males with M13_CERVICOBRACHSDR died.

Mortality risk

Mortality risk for people of age

years, who have M13_CERVICOBRACHSDR.

N-year risk Females Males
1 0.091% 0.126%
5 0.528% 1.173%
10 1.358% 3.025%
15 2.567% 5.839%
20 4.71% 10.057%

Relationships between endpoints

Index endpoint: M13_CERVICOBRACHSDR – Cervicobrachial syndrome

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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