Barre-Lieou syndrome: A syndrome that involves occipital head aches, nystagmus on head movement, tinnitus, spasms, blurred vision, corneal hyperaesthesia, and corneal ulcers.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
4206 |
4. Check minimum number of eventsNone |
4206 |
5. Include endpointsNone |
4206 |
6. Filter based on genotype QC (FinnGen only) |
4072 |
Control definitions (FinnGen only)
Control exclude
M13_DORSOPATHY
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M53
Name in latin
Syndroma cervicocraniale
Similar endpoints
↥List of similar endpoints to
Cervicocranial syndrome
based on the number of shared cases.
Similar with more cases:
- Other dorsopathies, not elsewhere classified
- Dorsopathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 33336 | 21995 | 11108 |
| Only index persons | 30013 | 20257 | 9756 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.52 | 0.63 | 0.31 |
| Only index persons | 0.62 | 0.74 | 0.37 |
| Median age at first event (years) | |||
| Whole population | 53.60 | 53.91 | 53.13 |
| Only index persons | 52.63 | 52.94 | 51.98 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 4072 | 2896 | 1176 |
| Unadjusted period prevalence (%) | 0.98 | 1.14 | 0.59 |
| Median age at first event (years) | 53.28 | 52.32 | 55.64 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_CERVICOCRANSDR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_CERVICOCRANSDR | 0.903 [0.81, 1.01] | 0.063 |
| Birth year | 0.994 [0.99, 1.0] | 0.167 |
During the follow-up period (1.1.1998 — 31.12.2019), 1651 out of 15413 females with M13_CERVICOCRANSDR died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_CERVICOCRANSDR | 0.943 [0.84, 1.06] | 0.311 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 1046 out of 7592 males with M13_CERVICOCRANSDR died.
Mortality risk
Mortality risk for people of age
years, who have M13_CERVICOCRANSDR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.081% | 0.17% |
| 5 | 0.512% | 1.076% |
| 10 | 1.251% | 2.633% |
| 15 | 2.462% | 4.937% |
| 20 | 4.302% | 8.479% |
Relationships between endpoints
↥Index endpoint: M13_CERVICOCRANSDR – Cervicocranial syndrome
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data