panniculitis: a group of diseases whose hallmark is inflammation of subcutaneous adipose tissue (the fatty layer under the skin - panniculus adiposus). Symptoms include tender skin nodules, and systemic signs such as weight loss and fatigue.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
1384 |
4. Check minimum number of eventsNone |
1384 |
5. Include endpointsNone |
1384 |
6. Filter based on genotype QC (FinnGen only) |
1327 |
Control definitions (FinnGen only)
Control exclude
M13_DORSOPATHY
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M54
Name in latin
Panniculitis dorsi
Similar endpoints
↥List of similar endpoints to
Panniculitis affecting regions of neck and back
based on the number of shared cases.
Similar with more cases:
- Dorsalgia
- Other dorsopathies, not elsewhere classified
- Dorsopathies
- Pain (limb, back, neck, head abdominally)
- Diseases of the musculoskeletal system and connective tissue
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 11769 | 7023 | 4671 |
| Only index persons | 10796 | 6492 | 4304 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.17 | 0.20 | 0.13 |
| Only index persons | 0.21 | 0.24 | 0.16 |
| Median age at first event (years) | |||
| Whole population | 52.31 | 53.52 | 50.27 |
| Only index persons | 50.66 | 51.95 | 48.72 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1327 | 823 | 504 |
| Unadjusted period prevalence (%) | 0.30 | 0.32 | 0.25 |
| Median age at first event (years) | 50.04 | 48.12 | 53.19 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_PANNICULITIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_PANNICULITIS | 1.578 [1.42, 1.75] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.048 |
During the follow-up period (1.1.1998 — 31.12.2019), 1665 out of 6737 females with M13_PANNICULITIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_PANNICULITIS | 1.505 [1.33, 1.71] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.011 |
During the follow-up period (1.1.1998 — 31.12.2019), 1019 out of 4499 males with M13_PANNICULITIS died.
Mortality risk
Mortality risk for people of age
years, who have M13_PANNICULITIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.143% | 0.272% |
| 5 | 0.799% | 1.826% |
| 10 | 1.882% | 4.562% |
| 15 | 3.762% | 8.391% |
| 20 | 6.781% | 14.191% |
Relationships between endpoints
↥Index endpoint: M13_PANNICULITIS – Panniculitis affecting regions of neck and back
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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