Sacrococcygeal disorders, not elsewhere classified

M13_SACROCOGG

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M53.3
  • Hospital discharge: ICD-9 7246
  • Cause of death: ICD-10 M53.3
  • Cause of death: ICD-9 7246

2 out of 7 registries used, show all original rules.

1107

4. Check minimum number of events

None

1107

5. Include endpoints

None

1107

6. Filter based on genotype QC (FinnGen only)

1071

Control definitions (FinnGen only)

Control exclude M13_DORSOPATHY

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M53
Name in latin Morbositates sacrococcygeales, non alibi classificatae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 7581 5556 1989
Only index persons 7232 5346 1886
Unadjusted period prevalence (%)
Whole population 0.13 0.16 0.06
Only index persons 0.16 0.20 0.07
Median age at first event (years)
Whole population 47.81 47.55 48.65
Only index persons 47.31 47.12 47.87

-FinnGen-

Key figures

All Female Male
Number of individuals 1071 864 207
Unadjusted period prevalence (%) 0.29 0.34 0.10
Median age at first event (years) 47.90 46.55 53.53

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint M13_SACROCOGG and mortality.

Females

Parameter HR [95% CI] p-value
M13_SACROCOGG 1.105 [0.97, 1.26] 0.129
Birth year 0.999 [0.99, 1.01] 0.725

During the follow-up period (1.1.1998 — 31.12.2019), 433 out of 4579 females with M13_SACROCOGG died.

Males

Parameter HR [95% CI] p-value
M13_SACROCOGG 1.055 [0.89, 1.25] 0.53
Birth year 0.986 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 222 out of 1642 males with M13_SACROCOGG died.

Mortality risk

Mortality risk for people of age

years, who have M13_SACROCOGG.

N-year risk Females Males
1 0.171% 0.205%
5 0.745% 1.24%
10 1.591% 3.116%
15 3.086% 5.96%
20 5.65% 9.9%

Relationships between endpoints

Index endpoint: M13_SACROCOGG – Sacrococcygeal disorders, not elsewhere classified

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data