Cervicalgia

M13_CERVICALGIA

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M54.2
  • Hospital discharge: ICD-9 7231
  • Hospital discharge: ICD-8 7289
  • Cause of death: ICD-10 M54.2
  • Cause of death: ICD-9 7231
  • Cause of death: ICD-8 7289

2 out of 7 registries used, show all original rules.

8704

4. Check minimum number of events

None

8704

5. Include endpoints

None

8704

6. Filter based on genotype QC (FinnGen only)

8371

Control definitions (FinnGen only)

Control exclude M13_DORSOPATHY

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M54
Name in latin Cervicalgia

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 73407 44449 28328
Only index persons 63185 39142 24043
Unadjusted period prevalence (%)
Whole population 1.08 1.27 0.79
Only index persons 1.24 1.44 0.92
Median age at first event (years)
Whole population 49.73 50.47 48.54
Only index persons 48.31 48.98 47.22

-FinnGen-

Key figures

All Female Male
Number of individuals 8371 5434 2937
Unadjusted period prevalence (%) 1.90 2.13 1.48
Median age at first event (years) 49.88 48.78 51.92

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint M13_CERVICALGIA and mortality.

Females

Parameter HR [95% CI] p-value
M13_CERVICALGIA 1.021 [0.91, 1.15] 0.728
Birth year 0.993 [0.98, 1.0] 0.095

During the follow-up period (1.1.1998 — 31.12.2019), 1823 out of 23001 females with M13_CERVICALGIA died.

Males

Parameter HR [95% CI] p-value
M13_CERVICALGIA 1.125 [0.99, 1.28] 0.068
Birth year 0.985 [0.98, 0.99] 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 1724 out of 15739 males with M13_CERVICALGIA died.

Mortality risk

Mortality risk for people of age

years, who have M13_CERVICALGIA.

N-year risk Females Males
1 0.085% 0.193%
5 0.545% 1.214%
10 1.35% 3.058%
15 2.623% 5.734%
20 4.585% 9.484%

Relationships between endpoints

Index endpoint: M13_CERVICALGIA – Cervicalgia

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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