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Pain in thoracic spine

EFO MESH Endpoint Browser PheWeb

M13_THORACISPINEPAIN

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M54.6
  • Hospital discharge: ICD-9 — 7241
  • Hospital discharge: ICD-8 — 7285
  • Cause of death: ICD-10 — M54.6
  • Cause of death: ICD-9 — 7241
  • Cause of death: ICD-8 — 7285

2 out of 7 registries used, show all original rules.

6158

4. Check minimum number of events

None

6158

5. Include endpoints

None

6158

6. Filter based on genotype QC (FinnGen only)

5912

Control definitions (FinnGen only)

Control exclude M13_DORSOPATHY

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M54
Name in latin Dolores columnae vertebralis thoracicae

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 48386 29497 18540
Only index persons 45580 28094 17486
Unadjusted period prevalence (%)
Whole population 0.72 0.84 0.52
Only index persons 0.89 1.03 0.67
Median age at first event (years)
Whole population 48.89 50.88 45.88
Only index persons 48.29 50.20 45.23

-FinnGen-

Key figures

All Female Male
Number of individuals 5912 4004 1908
Unadjusted period prevalence (%) 1.37 1.57 0.96
Median age at first event (years) 51.48 50.75 53.02

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint M13_THORACISPINEPAIN and mortality.

Females

Parameter HR [95% CI] p-value
M13_THORACISPINEPAIN 1.262 [1.11, 1.43] < 0.001
Birth year 0.993 [0.98, 1.0] 0.088

During the follow-up period (1.1.1998 — 31.12.2019), 2270 out of 22882 females with M13_THORACISPINEPAIN died.

Males

Parameter HR [95% CI] p-value
M13_THORACISPINEPAIN 1.301 [1.14, 1.48] < 0.001
Birth year 0.985 [0.98, 1.0] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 1434 out of 14128 males with M13_THORACISPINEPAIN died.

Mortality risk

Mortality risk for people of age

years, who have M13_THORACISPINEPAIN.

N-year risk Females Males
1 0.099% 0.215%
5 0.685% 1.413%
10 1.812% 3.448%
15 3.501% 6.686%
20 6.048% 11.686%

Relationships between endpoints

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Index endpoint: M13_THORACISPINEPAIN – Pain in thoracic spine

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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