eye disease: A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma. [NCIt:C26767]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
5009 |
4. Check minimum number of eventsNone |
5009 |
5. Include endpoints |
5266 |
6. Filter based on genotype QC (FinnGen only) |
5025 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Other disorders of eye and adnexa
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 43904 | 25826 | 17755 |
| Only index persons | 38691 | 23232 | 15459 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.64 | 0.74 | 0.50 |
| Only index persons | 0.75 | 0.85 | 0.59 |
| Median age at first event (years) | |||
| Whole population | 43.93 | 46.89 | 39.65 |
| Only index persons | 43.88 | 46.43 | 40.04 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 5025 | 3450 | 1575 |
| Unadjusted period prevalence (%) | 1.18 | 1.35 | 0.79 |
| Median age at first event (years) | 49.99 | 48.71 | 52.80 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_EYEOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_EYEOTH | 1.122 [1.01, 1.25] | 0.037 |
| Birth year | 0.992 [0.98, 1.0] | 0.058 |
During the follow-up period (1.1.1998 — 31.12.2019), 1906 out of 19641 females with H7_EYEOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_EYEOTH | 1.291 [1.14, 1.46] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.013 |
During the follow-up period (1.1.1998 — 31.12.2019), 1572 out of 13777 males with H7_EYEOTH died.
Mortality risk
Mortality risk for people of age
years, who have H7_EYEOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.103% | 0.306% |
| 5 | 0.63% | 1.639% |
| 10 | 1.546% | 3.821% |
| 15 | 2.869% | 7.301% |
| 20 | 4.748% | 12.358% |
Relationships between endpoints
↥Index endpoint: H7_EYEOTH – Other disorders of eye and adnexa
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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