No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
457 |
4. Check minimum number of eventsNone |
457 |
5. Include endpointsNone |
457 |
6. Filter based on genotype QC (FinnGen only) |
437 |
Control definitions (FinnGen only)
Control exclude
H7_EYEOTH
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
H55-H59
Name in latin
Nystagmus et alii motus irregulares oculi
Similar endpoints
↥List of similar endpoints to
Nystagmus and other irregular eye movements
based on the number of shared cases.
Similar with more cases:
- Other disorders of eye and adnexa
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4714 | 2279 | 2421 |
| Only index persons | 3952 | 1959 | 1993 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.07 | 0.07 |
| Only index persons | 0.07 | 0.07 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 25.97 | 30.97 | 21.18 |
| Only index persons | 32.97 | 36.00 | 30.00 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 437 | 259 | 178 |
| Unadjusted period prevalence (%) | 0.10 | 0.10 | 0.09 |
| Median age at first event (years) | 45.17 | 44.19 | 46.60 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint H7_NYSTAGMUS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_NYSTAGMUS | 1.772 [1.39, 2.25] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.166 |
During the follow-up period (1.1.1998 — 31.12.2019), 175 out of 1946 females with H7_NYSTAGMUS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_NYSTAGMUS | 2.021 [1.62, 2.52] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 210 out of 2046 males with H7_NYSTAGMUS died.
Mortality risk
Mortality risk for people of age
years, who have H7_NYSTAGMUS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.126% | 0.334% |
| 5 | 1.05% | 2.326% |
| 10 | 2.605% | 5.471% |
| 15 | 4.768% | 10.192% |
| 20 | 8.138% | 17.425% |
Relationships between endpoints
↥Index endpoint: H7_NYSTAGMUS – Nystagmus and other irregular eye movements
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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