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Other specified and unspecified disorders of eye and adnexa

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H7_EYEADNEXOTH

eye disease: A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma. [NCIt:C26767]

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H57.8, H57.9
  • Hospital discharge: ICD-9 — 379[8-9]
  • Hospital discharge: ICD-8 — 37898
  • Cause of death: ICD-10 — H57.8, H57.9
  • Cause of death: ICD-9 — 379[8-9]
  • Cause of death: ICD-8 — 37898

2 out of 7 registries used, show all original rules.

1320

4. Check minimum number of events

None

1320

5. Include endpoints

None

1320

6. Filter based on genotype QC (FinnGen only)

1266

Control definitions (FinnGen only)

Control exclude H7_EYEOTH

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 12111 7188 4811
Only index persons 9719 5826 3893
Unadjusted period prevalence (%)
Whole population 0.18 0.21 0.13
Only index persons 0.19 0.21 0.15
Median age at first event (years)
Whole population 47.98 51.02 43.22
Only index persons 43.84 47.44 38.46

-FinnGen-

Key figures

All Female Male
Number of individuals 1266 813 453
Unadjusted period prevalence (%) 0.29 0.32 0.23
Median age at first event (years) 48.33 46.95 50.80

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint H7_EYEADNEXOTH and mortality.

Females

Parameter HR [95% CI] p-value
H7_EYEADNEXOTH 1.196 [1.08, 1.33] < 0.001
Birth year 0.993 [0.98, 1.0] 0.114

During the follow-up period (1.1.1998 — 31.12.2019), 690 out of 4383 females with H7_EYEADNEXOTH died.

Males

Parameter HR [95% CI] p-value
H7_EYEADNEXOTH 1.306 [1.15, 1.49] < 0.001
Birth year 0.989 [0.98, 1.0] 0.022

During the follow-up period (1.1.1998 — 31.12.2019), 533 out of 3224 males with H7_EYEADNEXOTH died.

Mortality risk

Mortality risk for people of age

years, who have H7_EYEADNEXOTH.

N-year risk Females Males
1 0.113% 0.234%
5 0.623% 1.597%
10 1.492% 3.945%
15 2.92% 7.62%
20 5.275% 13.355%

Relationships between endpoints

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Index endpoint: H7_EYEADNEXOTH – Other specified and unspecified disorders of eye and adnexa

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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