Postprocedural disorders of eye and adnexa, not elsewhere classified

H7_EYEPOSTOP

eye disease: A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma. [NCIt:C26767]

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H59
  • Cause of death: ICD-10 H59

2 out of 7 registries used, show all original rules.

75

4. Check minimum number of events

None

75

5. Include endpoints

75

6. Filter based on genotype QC (FinnGen only)

68

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H55-H59
Name in latin Morbositates oculi et organorum accessoriorum post interventiones non alibi classificatae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 873 487 378
Only index persons 737 418 319
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.02 0.01
Median age at first event (years)
Whole population 72.77 74.62 70.31
Only index persons 71.58 73.40 69.20

-FinnGen-

Key figures

All Female Male
Number of individuals 68 40 28
Unadjusted period prevalence (%) 0.02 0.02 0.01
Median age at first event (years) 70.69 72.69 67.83

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint H7_EYEPOSTOP and mortality.

Females

Parameter HR [95% CI] p-value
H7_EYEPOSTOP 1.239 [0.99, 1.54] 0.057
Birth year 0.994 [0.99, 1.0] 0.174

During the follow-up period (1.1.1998 — 31.12.2019), 153 out of 404 females with H7_EYEPOSTOP died.

Males

Parameter HR [95% CI] p-value
H7_EYEPOSTOP 1.275 [0.95, 1.71] 0.102
Birth year 0.986 [0.98, 1.0] 0.005

During the follow-up period (1.1.1998 — 31.12.2019), 132 out of 311 males with H7_EYEPOSTOP died.

Mortality risk

Mortality risk for people of age

years, who have H7_EYEPOSTOP.

N-year risk Females Males
1 0.117% 0.248%
5 0.685% 1.393%
10 1.707% 3.671%
15 3.339% 6.617%
20 5.871% 11.493%

Relationships between endpoints

Index endpoint: H7_EYEPOSTOP – Postprocedural disorders of eye and adnexa, not elsewhere classified

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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