No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
675 |
4. Check minimum number of eventsNone |
675 |
5. Include endpointsNone |
675 |
6. Filter based on genotype QC (FinnGen only) |
653 |
Control definitions (FinnGen only)
Control exclude
H7_EYEOTH
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Anomalies of pupillary function
based on the number of shared cases.
Similar with more cases:
- Other disorders of eye and adnexa
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5859 | 3670 | 2172 |
| Only index persons | 5135 | 3304 | 1831 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.11 | 0.06 |
| Only index persons | 0.10 | 0.12 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 38.54 | 40.94 | 34.48 |
| Only index persons | 41.34 | 42.94 | 38.47 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 653 | 468 | 185 |
| Unadjusted period prevalence (%) | 0.16 | 0.18 | 0.09 |
| Median age at first event (years) | 45.68 | 45.55 | 46.01 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_ANOMAPUPFUNC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_ANOMAPUPFUNC | 1.182 [0.96, 1.46] | 0.124 |
| Birth year | 0.993 [0.98, 1.0] | 0.099 |
During the follow-up period (1.1.1998 — 31.12.2019), 169 out of 2968 females with H7_ANOMAPUPFUNC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_ANOMAPUPFUNC | 1.53 [1.15, 2.03] | 0.003 |
| Birth year | 0.99 [0.98, 1.0] | 0.032 |
During the follow-up period (1.1.1998 — 31.12.2019), 134 out of 1746 males with H7_ANOMAPUPFUNC died.
Mortality risk
Mortality risk for people of age
years, who have H7_ANOMAPUPFUNC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.131% | 0.289% |
| 5 | 0.718% | 1.814% |
| 10 | 1.711% | 4.479% |
| 15 | 3.221% | 8.656% |
| 20 | 5.523% | 14.409% |
Relationships between endpoints
↥Index endpoint: H7_ANOMAPUPFUNC – Anomalies of pupillary function
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data