No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
36238 |
4. Check minimum number of eventsNone |
36238 |
5. Include endpointsNone |
36238 |
6. Filter based on genotype QC (FinnGen only) |
34952 |
Control definitions (FinnGen only)
Control exclude
PAIN
Extra metadata
First used in FinnGen datafreeze
DF3
Parent code in ICD-10
M25
Name in latin
Arthralgia
Pain in joint
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 261287 | 159755 | 100459 |
| Only index persons | 249185 | 153957 | 95228 |
| Unadjusted period prevalence (%) | |||
| Whole population | 3.88 | 4.58 | 2.81 |
| Only index persons | 4.89 | 5.66 | 3.64 |
| Median age at first event (years) | |||
| Whole population | 43.78 | 44.93 | 41.99 |
| Only index persons | 43.97 | 45.00 | 42.31 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 34952 | 24223 | 10729 |
| Unadjusted period prevalence (%) | 8.25 | 9.51 | 5.39 |
| Median age at first event (years) | 48.33 | 46.90 | 51.55 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint JOINTPAIN and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| JOINTPAIN | 1.012 [0.92, 1.12] | 0.802 |
| Birth year | 0.994 [0.99, 1.0] | 0.156 |
During the follow-up period (1.1.1998 — 31.12.2019), 9175 out of 134317 females with JOINTPAIN died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| JOINTPAIN | 1.072 [0.98, 1.18] | 0.144 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 7423 out of 83247 males with JOINTPAIN died.
Mortality risk
Mortality risk for people of age
years, who have JOINTPAIN.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.094% | 0.193% |
| 5 | 0.508% | 1.113% |
| 10 | 1.386% | 3.032% |
| 15 | 2.836% | 5.925% |
| 20 | 4.971% | 9.673% |
Relationships between endpoints
↥Index endpoint: JOINTPAIN – Pain in joint
GWS hits: 5
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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