peripheral nervous system disease: A disease involving the peripheral nervous system.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
81 |
4. Check minimum number of eventsNone |
81 |
5. Include endpointsNone |
81 |
6. Filter based on genotype QC (FinnGen only) |
81 |
Control definitions (FinnGen only)
Control exclude
PAIN
Extra metadata
First used in FinnGen datafreeze
DF3
Parent code in ICD-10
G54
Name in latin
Syndroma phantomatis membri dolorosum
Similar endpoints
↥List of similar endpoints to
Phantom limb syndrome with pain
based on the number of shared cases.
Similar with more cases:
- Nerve, nerve root and plexus disorders
- Neurological diseases
- Neurological diseases
- Pain (limb, back, neck, head abdominally)
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 707 | 296 | 401 |
| Only index persons | 573 | 236 | 337 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 55.87 | 56.33 | 55.27 |
| Only index persons | 53.44 | 53.66 | 53.29 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 81 | 36 | 45 |
| Unadjusted period prevalence (%) | 0.02 | 0.01 | 0.02 |
| Median age at first event (years) | 55.37 | 50.45 | 59.31 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint PHANTOMLIMB and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| PHANTOMLIMB | 2.807 [1.79, 4.39] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.11 |
During the follow-up period (1.1.1998 — 31.12.2019), 90 out of 255 females with PHANTOMLIMB died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| PHANTOMLIMB | 2.059 [1.54, 2.76] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 116 out of 349 males with PHANTOMLIMB died.
Mortality risk
Mortality risk for people of age
years, who have PHANTOMLIMB.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.292% | 0.332% |
| 5 | 1.62% | 1.938% |
| 10 | 4.051% | 5.199% |
| 15 | 7.699% | 10.008% |
| 20 | 12.73% | 16.672% |
Relationships between endpoints
↥Index endpoint: PHANTOMLIMB – Phantom limb syndrome with pain
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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