Phantom limb syndrome with pain

PHANTOMLIMB

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 G54.6
  • Hospital discharge: ICD-9 3536
  • Cause of death: ICD-10 G54.6
  • Cause of death: ICD-9 3536

2 out of 7 registries used, show all original rules.

81

4. Check minimum number of events

None

81

5. Include endpoints

None

81

6. Filter based on genotype QC (FinnGen only)

81

Control definitions (FinnGen only)

Control exclude PAIN

Extra metadata

First used in FinnGen datafreeze DF3
Parent code in ICD-10 G54
Name in latin Syndroma phantomatis membri dolorosum

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 707 296 401
Only index persons 573 236 337
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 55.87 56.33 55.27
Only index persons 53.44 53.66 53.29

-FinnGen-

Key figures

All Female Male
Number of individuals 81 36 45
Unadjusted period prevalence (%) 0.02 0.01 0.02
Median age at first event (years) 55.37 50.45 59.31

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint PHANTOMLIMB and mortality.

Females

Parameter HR [95% CI] p-value
PHANTOMLIMB 2.807 [1.79, 4.39] < 0.001
Birth year 0.993 [0.98, 1.0] 0.11

During the follow-up period (1.1.1998 — 31.12.2019), 90 out of 255 females with PHANTOMLIMB died.

Males

Parameter HR [95% CI] p-value
PHANTOMLIMB 2.059 [1.54, 2.76] < 0.001
Birth year 0.984 [0.97, 0.99] 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 116 out of 349 males with PHANTOMLIMB died.

Mortality risk

Mortality risk for people of age

years, who have PHANTOMLIMB.

N-year risk Females Males
1 0.292% 0.332%
5 1.62% 1.938%
10 4.051% 5.199%
15 7.699% 10.008%
20 12.73% 16.672%

Relationships between endpoints

Index endpoint: PHANTOMLIMB – Phantom limb syndrome with pain

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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