cranial nerve palsy: Injury to any of the cranial nerves or their nuclei in the brain resulting in muscle weakness.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
440 |
4. Check minimum number of eventsNone |
440 |
5. Include endpointsNone |
440 |
6. Filter based on genotype QC (FinnGen only) |
420 |
Control definitions (FinnGen only)
Control exclude
G6_NERPLEX
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Postzoster neuralgia
based on the number of shared cases.
Similar with more cases:
- Nerve, nerve root and plexus disorders
- Neurological diseases
- Neurological diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3542 | 2189 | 1325 |
| Only index persons | 3234 | 2038 | 1196 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.06 | 0.04 |
| Only index persons | 0.06 | 0.07 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 75.27 | 76.62 | 72.99 |
| Only index persons | 74.95 | 76.35 | 72.58 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 420 | 247 | 173 |
| Unadjusted period prevalence (%) | 0.09 | 0.10 | 0.09 |
| Median age at first event (years) | 71.66 | 71.45 | 71.97 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint G6_POSTZOST and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_POSTZOST | 1.259 [1.07, 1.48] | 0.005 |
| Birth year | 0.995 [0.99, 1.0] | 0.291 |
During the follow-up period (1.1.1998 — 31.12.2019), 668 out of 1848 females with G6_POSTZOST died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_POSTZOST | 1.483 [1.21, 1.82] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.031 |
During the follow-up period (1.1.1998 — 31.12.2019), 466 out of 1086 males with G6_POSTZOST died.
Mortality risk
Mortality risk for people of age
years, who have G6_POSTZOST.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.109% | 0.277% |
| 5 | 0.642% | 1.793% |
| 10 | 1.732% | 4.78% |
| 15 | 3.376% | 8.816% |
| 20 | 6.006% | 14.731% |
Relationships between endpoints
↥Index endpoint: G6_POSTZOST – Postzoster neuralgia
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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