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Other and unspecified trigeminal disorders

DOID EFO Endpoint Browser PheWeb

G6_TRIOTHUNS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — G50.8, G50.9
  • Hospital discharge: ICD-9 — 350[8-9]
  • Hospital discharge: ICD-8 — 35601
  • Cause of death: ICD-10 — G50.8, G50.9
  • Cause of death: ICD-9 — 350[8-9]
  • Cause of death: ICD-8 — 35601

2 out of 7 registries used, show all original rules.

525

4. Check minimum number of events

None

525

5. Include endpoints

None

525

6. Filter based on genotype QC (FinnGen only)

510

Control definitions (FinnGen only)

Control exclude G6_NERPLEX

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3637 2471 1148
Only index persons 3305 2291 1014
Unadjusted period prevalence (%)
Whole population 0.06 0.07 0.03
Only index persons 0.07 0.08 0.04
Median age at first event (years)
Whole population 53.77 53.33 54.63
Only index persons 52.31 52.25 52.47

-FinnGen-

Key figures

All Female Male
Number of individuals 510 366 144
Unadjusted period prevalence (%) 0.12 0.14 0.07
Median age at first event (years) 54.22 52.97 57.41

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint G6_TRIOTHUNS and mortality.

Females

Parameter HR [95% CI] p-value
G6_TRIOTHUNS 1.485 [1.28, 1.73] < 0.001
Birth year 0.997 [0.99, 1.01] 0.513

During the follow-up period (1.1.1998 — 31.12.2019), 381 out of 2062 females with G6_TRIOTHUNS died.

Males

Parameter HR [95% CI] p-value
G6_TRIOTHUNS 1.674 [1.35, 2.07] < 0.001
Birth year 0.986 [0.98, 1.0] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 247 out of 930 males with G6_TRIOTHUNS died.

Mortality risk

Mortality risk for people of age

years, who have G6_TRIOTHUNS.

N-year risk Females Males
1 0.131% 0.338%
5 0.889% 1.895%
10 2.321% 4.687%
15 4.569% 8.682%
20 7.835% 14.589%

Relationships between endpoints

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Index endpoint: G6_TRIOTHUNS – Other and unspecified trigeminal disorders

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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