mononeuropathy: Disease or trauma involving a single peripheral nerve in isolation, or out of proportion to evidence of diffuse peripheral nerve dysfunction. Mononeuropathy multiplex refers to a condition characterized by multiple isolated nerve injuries. Mononeuropathies may result from a wide variety of causes, including ischemia; traumatic injury; compression; connective tissue diseases; cumulative trauma disorders; and other conditions.
Other and unspecified mononeuropathies of lower limb
DOID EFO Endpoint Browser PheWeb
G6_MONOLOWOTHUNS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
942 |
4. Check minimum number of eventsNone |
942 |
5. Include endpointsNone |
942 |
6. Filter based on genotype QC (FinnGen only) |
914 |
Control definitions (FinnGen only)
Control exclude
G6_NERPLEX
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified mononeuropathies of lower limb
based on the number of shared cases.
Similar with more cases:
- Nerve, nerve root and plexus disorders
- Neurological diseases
- Neurological diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 6122 | 3829 | 2260 |
| Only index persons | 5614 | 3606 | 2008 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.11 | 0.06 |
| Only index persons | 0.11 | 0.13 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 51.76 | 52.07 | 51.23 |
| Only index persons | 50.93 | 51.59 | 49.75 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 914 | 634 | 280 |
| Unadjusted period prevalence (%) | 0.22 | 0.25 | 0.14 |
| Median age at first event (years) | 52.65 | 51.70 | 54.80 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint G6_MONOLOWOTHUNS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_MONOLOWOTHUNS | 1.054 [0.91, 1.22] | 0.49 |
| Birth year | 0.998 [0.99, 1.01] | 0.682 |
During the follow-up period (1.1.1998 — 31.12.2019), 254 out of 2459 females with G6_MONOLOWOTHUNS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_MONOLOWOTHUNS | 1.209 [1.02, 1.44] | 0.03 |
| Birth year | 0.986 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 237 out of 1432 males with G6_MONOLOWOTHUNS died.
Mortality risk
Mortality risk for people of age
years, who have G6_MONOLOWOTHUNS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.109% | 0.254% |
| 5 | 0.697% | 1.393% |
| 10 | 1.702% | 3.453% |
| 15 | 3.286% | 6.648% |
| 20 | 5.71% | 10.85% |
Relationships between endpoints
↥Index endpoint: G6_MONOLOWOTHUNS – Other and unspecified mononeuropathies of lower limb
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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