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Lesion of radial nerve

DOID EFO Endpoint Browser PheWeb

G6_RADLES

radial nerve lesion: Disease involving the RADIAL NERVE. Clinical features include weakness of elbow extension, elbow flexion, supination of the forearm, wrist and finger extension, and thumb abduction. Sensation may be impaired over regions of the dorsal forearm. Common sites of compression or traumatic injury include the AXILLA and radial groove of the HUMERUS.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — G56.3
  • Hospital discharge: ICD-9 — 3543
  • Hospital discharge: ICD-8 — 35708
  • Cause of death: ICD-10 — G56.3
  • Cause of death: ICD-9 — 3543
  • Cause of death: ICD-8 — 35708

2 out of 7 registries used, show all original rules.

1291

4. Check minimum number of events

None

1291

5. Include endpoints

None

1291

6. Filter based on genotype QC (FinnGen only)

1253

Control definitions (FinnGen only)

Control exclude G6_NERPLEX

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G56
Name in latin Morbositas nervi radialis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 12767 5812 6831
Only index persons 10899 5141 5758
Unadjusted period prevalence (%)
Whole population 0.18 0.17 0.19
Only index persons 0.21 0.19 0.22
Median age at first event (years)
Whole population 47.76 48.45 47.09
Only index persons 46.47 47.45 45.60

-FinnGen-

Key figures

All Female Male
Number of individuals 1253 643 610
Unadjusted period prevalence (%) 0.28 0.25 0.31
Median age at first event (years) 46.25 44.02 48.61

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint G6_RADLES and mortality.

Females

Parameter HR [95% CI] p-value
G6_RADLES 1.755 [1.48, 2.08] < 0.001
Birth year 1.0 [0.99, 1.01] 0.93

During the follow-up period (1.1.1998 — 31.12.2019), 447 out of 2781 females with G6_RADLES died.

Males

Parameter HR [95% CI] p-value
G6_RADLES 2.215 [1.93, 2.54] < 0.001
Birth year 0.986 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 841 out of 4105 males with G6_RADLES died.

Mortality risk

Mortality risk for people of age

years, who have G6_RADLES.

N-year risk Females Males
1 0.222% 0.423%
5 1.16% 2.483%
10 2.982% 6.39%
15 5.825% 11.879%
20 10.144% 18.813%

Relationships between endpoints

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Index endpoint: G6_RADLES – Lesion of radial nerve

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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