No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
90484 |
4. Check minimum number of eventsNone |
90484 |
5. Include endpoints
|
102994 |
6. Filter based on genotype QC (FinnGen only) |
99586 |
Control definitions (FinnGen only)
Control exclude
M13_ARTHROPATHIES
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other joint disorders
based on the number of shared cases.
Similar with more cases:
- Arthropathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 852551 | 487308 | 361290 |
| Only index persons | 790503 | 455570 | 334933 |
| Unadjusted period prevalence (%) | |||
| Whole population | 12.27 | 13.96 | 10.09 |
| Only index persons | 15.07 | 16.75 | 12.79 |
| Median age at first event (years) | |||
| Whole population | 45.37 | 48.05 | 41.73 |
| Only index persons | 44.67 | 47.32 | 41.06 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 99586 | 62579 | 37007 |
| Unadjusted period prevalence (%) | 22.35 | 24.58 | 18.59 |
| Median age at first event (years) | 47.16 | 46.87 | 47.65 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_OTHERJOINT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_OTHERJOINT | 0.92 [0.85, 1.0] | 0.045 |
| Birth year | 0.993 [0.99, 1.0] | 0.089 |
During the follow-up period (1.1.1998 — 31.12.2019), 24867 out of 323681 females with M13_OTHERJOINT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_OTHERJOINT | 0.866 [0.8, 0.94] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.016 |
During the follow-up period (1.1.1998 — 31.12.2019), 22195 out of 241970 males with M13_OTHERJOINT died.
Mortality risk
Mortality risk for people of age
years, who have M13_OTHERJOINT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.074% | 0.165% |
| 5 | 0.43% | 1.058% |
| 10 | 1.096% | 2.614% |
| 15 | 2.218% | 4.85% |
| 20 | 4.016% | 8.383% |
Relationships between endpoints
↥Index endpoint: M13_OTHERJOINT – Other joint disorders
GWS hits: 25
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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