No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
368 |
4. Check minimum number of eventsNone |
368 |
5. Include endpointsNone |
368 |
6. Filter based on genotype QC (FinnGen only) |
350 |
Control definitions (FinnGen only)
Control exclude
M13_ARTHROPATHIES
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M21
Name in latin
Deformitas membri vara non alibi classificata
Similar endpoints
↥List of similar endpoints to
Varus deformity, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Other joint disorders
- Arthropathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3785 | 2650 | 1120 |
| Only index persons | 3415 | 2455 | 960 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.08 | 0.03 |
| Only index persons | 0.08 | 0.09 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 51.91 | 55.37 | 43.69 |
| Only index persons | 51.77 | 54.93 | 43.71 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 350 | 286 | 64 |
| Unadjusted period prevalence (%) | 0.10 | 0.11 | 0.03 |
| Median age at first event (years) | 50.98 | 51.44 | 48.95 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint M13_VARUS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_VARUS | 0.983 [0.85, 1.14] | 0.816 |
| Birth year | 0.994 [0.99, 1.0] | 0.151 |
During the follow-up period (1.1.1998 — 31.12.2019), 249 out of 2081 females with M13_VARUS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_VARUS | 0.887 [0.73, 1.08] | 0.242 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 98 out of 763 males with M13_VARUS died.
Mortality risk
Mortality risk for people of age
years, who have M13_VARUS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.074% | 0.182% |
| 5 | 0.453% | 1.075% |
| 10 | 1.299% | 2.474% |
| 15 | 2.626% | 4.632% |
| 20 | 4.587% | 7.824% |
Relationships between endpoints
↥Index endpoint: M13_VARUS – Varus deformity, not elsewhere classified
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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