joint disease: Any disorder of the joints.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
160435 |
4. Check minimum number of eventsNone |
160435 |
5. Include endpoints |
171661 |
6. Filter based on genotype QC (FinnGen only) |
165937 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Arthropathies
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1510149 | 846625 | 653970 |
| Only index persons | 1327515 | 753653 | 573862 |
| Unadjusted period prevalence (%) | |||
| Whole population | 21.57 | 24.25 | 18.27 |
| Only index persons | 25.20 | 27.71 | 21.91 |
| Median age at first event (years) | |||
| Whole population | 52.34 | 53.85 | 50.30 |
| Only index persons | 50.88 | 52.57 | 48.66 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 165937 | 97456 | 68481 |
| Unadjusted period prevalence (%) | 36.67 | 38.28 | 34.39 |
| Median age at first event (years) | 51.71 | 50.51 | 53.42 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_ARTHROPATHIES and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_ARTHROPATHIES | 0.987 [0.92, 1.06] | 0.734 |
| Birth year | 0.996 [0.99, 1.0] | 0.237 |
During the follow-up period (1.1.1998 — 31.12.2019), 77568 out of 548101 females with M13_ARTHROPATHIES died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_ARTHROPATHIES | 1.062 [0.98, 1.15] | 0.124 |
| Birth year | 0.989 [0.98, 1.0] | 0.009 |
During the follow-up period (1.1.1998 — 31.12.2019), 68633 out of 427855 males with M13_ARTHROPATHIES died.
Mortality risk
Mortality risk for people of age
years, who have M13_ARTHROPATHIES.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.088% | 0.179% |
| 5 | 0.474% | 1.072% |
| 10 | 1.394% | 2.848% |
| 15 | 2.6% | 5.336% |
| 20 | 4.67% | 9.286% |
Relationships between endpoints
↥Index endpoint: M13_ARTHROPATHIES – Arthropathies
GWS hits: 33
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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