A noninflammatory degenerative joint disease occurring chiefly in older persons, characterised by degeneration of the articular cartilage, hypertrophy of bone at the margins and changes in the synovial membrane. It is accompanied by pain and stiffness, particularly after prolonged activity.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
56213 |
4. Check minimum number of eventsNone |
56213 |
5. Include endpointsNone |
56213 |
6. Filter based on genotype QC (FinnGen only) |
54570 |
Control definitions (FinnGen only)
Control exclude
M13_ARTHROPATHIES
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M15-M19
Name in latin
Gonarthrosis
Similar endpoints
↥List of similar endpoints to
Gonarthrosis
based on the number of shared cases.
Similar with more cases:
- Gonarthrosis [arthrosis of knee](FG)
- Arthrosis
- Finngen Rheumatological endpoints
- Artrosis, including avohilmo
- Arthropathies
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 449784 | 273379 | 174237 |
| Only index persons | 403176 | 246336 | 156840 |
| Unadjusted period prevalence (%) | |||
| Whole population | 6.66 | 7.83 | 4.87 |
| Only index persons | 7.86 | 9.06 | 5.99 |
| Median age at first event (years) | |||
| Whole population | 61.87 | 63.63 | 59.06 |
| Only index persons | 60.94 | 62.59 | 58.36 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 54570 | 32275 | 22295 |
| Unadjusted period prevalence (%) | 12.07 | 12.68 | 11.20 |
| Median age at first event (years) | 59.36 | 59.28 | 59.48 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_ARTHROSIS_KNEE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_ARTHROSIS_KNEE | 0.893 [0.83, 0.96] | 0.002 |
| Birth year | 0.992 [0.98, 1.0] | 0.046 |
During the follow-up period (1.1.1998 — 31.12.2019), 40492 out of 198404 females with M13_ARTHROSIS_KNEE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_ARTHROSIS_KNEE | 0.87 [0.81, 0.94] | < 0.001 |
| Birth year | 0.986 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 25339 out of 127149 males with M13_ARTHROSIS_KNEE died.
Mortality risk
Mortality risk for people of age
years, who have M13_ARTHROSIS_KNEE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.078% | 0.165% |
| 5 | 0.395% | 0.966% |
| 10 | 1.049% | 2.443% |
| 15 | 2.073% | 4.52% |
| 20 | 3.722% | 7.823% |
Relationships between endpoints
↥Index endpoint: M13_ARTHROSIS_KNEE – Gonarthrosis
GWS hits: 70
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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