No definition available.
Gonarthrosis, primary, with knee surgery
EFO MESH Endpoint Browser PheWeb
M13_ARTHROSIS_KNEE_PRIM_KNEESURG
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditions
|
50286 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
24067 |
4. Check minimum number of eventsNone |
24067 |
5. Include endpointsNone |
24067 |
6. Filter based on genotype QC (FinnGen only) |
23441 |
Control definitions (FinnGen only)
Control conditions
not M13_ARTHROSIS_KNEE_PRIM_ICD10
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF3
Similar endpoints
↥List of similar endpoints to
Gonarthrosis, primary, with knee surgery
based on the number of shared cases.
Similar with more cases:
- Gonarthrosis,primary
- Gonarthrosis
- Gonarthrosis [arthrosis of knee](FG)
- Arthrosis
- Finngen Rheumatological endpoints
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 167712 | 109905 | 57409 |
| Only index persons | 159788 | 105159 | 54629 |
| Unadjusted period prevalence (%) | |||
| Whole population | 2.61 | 3.15 | 1.60 |
| Only index persons | 3.26 | 3.87 | 2.09 |
| Median age at first event (years) | |||
| Whole population | 69.62 | 70.34 | 68.20 |
| Only index persons | 69.30 | 70.03 | 67.88 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 23441 | 14442 | 8999 |
| Unadjusted period prevalence (%) | 5.23 | 5.67 | 4.52 |
| Median age at first event (years) | 66.99 | 66.65 | 67.53 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_ARTHROSIS_KNEE_PRIM_KNEESURG and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_ARTHROSIS_KNEE_PRIM_KNEESURG | 0.861 [0.8, 0.93] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.058 |
During the follow-up period (1.1.1998 — 31.12.2019), 22509 out of 95531 females with M13_ARTHROSIS_KNEE_PRIM_KNEESURG died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_ARTHROSIS_KNEE_PRIM_KNEESURG | 0.825 [0.76, 0.89] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 11985 out of 49089 males with M13_ARTHROSIS_KNEE_PRIM_KNEESURG died.
Mortality risk
Mortality risk for people of age
years, who have M13_ARTHROSIS_KNEE_PRIM_KNEESURG.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.087% | 0.175% |
| 5 | 0.361% | 0.927% |
| 10 | 1.037% | 2.424% |
| 15 | 2.024% | 4.468% |
| 20 | 3.662% | 7.439% |
Relationships between endpoints
↥Index endpoint: M13_ARTHROSIS_KNEE_PRIM_KNEESURG – Gonarthrosis, primary, with knee surgery
GWS hits: 44
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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