No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
21410 |
4. Check minimum number of eventsNone |
21410 |
5. Include endpointsNone |
21410 |
6. Filter based on genotype QC (FinnGen only) |
20783 |
Control definitions (FinnGen only)
Control exclude
KNEE_ARTHROSIS
Extra metadata
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M17
Name in latin
Gonarthrosis primaria bilateralis
Similar endpoints
↥List of similar endpoints to
Primary gonarthrosis, bilateral
based on the number of shared cases.
Similar with more cases:
- Gonarthrosis,primary
- Gonarthrosis [arthrosis of knee](FG)
- Gonarthrosis
- Arthrosis
- Finngen Rheumatological endpoints
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 159545 | 103312 | 55740 |
| Only index persons | 149586 | 97271 | 52315 |
| Unadjusted period prevalence (%) | |||
| Whole population | 2.46 | 2.96 | 1.56 |
| Only index persons | 3.02 | 3.58 | 2.00 |
| Median age at first event (years) | |||
| Whole population | 68.02 | 69.24 | 65.73 |
| Only index persons | 67.41 | 68.62 | 65.14 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 20783 | 12787 | 7996 |
| Unadjusted period prevalence (%) | 4.63 | 5.02 | 4.02 |
| Median age at first event (years) | 64.41 | 63.94 | 65.17 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint PRIM_KNEEARTHROSIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| PRIM_KNEEARTHROSIS | 0.939 [0.87, 1.01] | 0.083 |
| Birth year | 0.995 [0.99, 1.0] | 0.216 |
During the follow-up period (1.1.1998 — 31.12.2019), 22866 out of 88898 females with PRIM_KNEEARTHROSIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| PRIM_KNEEARTHROSIS | 0.92 [0.85, 1.0] | 0.045 |
| Birth year | 0.985 [0.98, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 11947 out of 47710 males with PRIM_KNEEARTHROSIS died.
Mortality risk
Mortality risk for people of age
years, who have PRIM_KNEEARTHROSIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.09% | 0.123% |
| 5 | 0.568% | 0.92% |
| 10 | 1.367% | 2.376% |
| 15 | 2.551% | 4.561% |
| 20 | 4.535% | 7.831% |
Relationships between endpoints
↥Index endpoint: PRIM_KNEEARTHROSIS – Primary gonarthrosis, bilateral
GWS hits: 36
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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