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Pyogenic arthritis

DOID EFO Endpoint Browser PheWeb

M13_PYOGARTH

infectious arthritis: The inflammation of one or more joints caused by a bacterial infection within the joint space. Symptoms include pain, stiffness, and decreased range of motion in the affected joint.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M00, M01*
  • Hospital discharge: ICD-9 — 7110|7119
  • Hospital discharge: ICD-8 — 710
  • Cause of death: ICD-10 — M00, M01*
  • Cause of death: ICD-9 — 7110|7119
  • Cause of death: ICD-8 — 710

2 out of 7 registries used, show all original rules.

2535

4. Check minimum number of events

None

2535

5. Include endpoints

None

2535

6. Filter based on genotype QC (FinnGen only)

2441

Control definitions (FinnGen only)

Control exclude M13_ARTHROPATHIES

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 26115 11132 14752
Only index persons 21100 8907 12193
Unadjusted period prevalence (%)
Whole population 0.37 0.32 0.41
Only index persons 0.41 0.33 0.47
Median age at first event (years)
Whole population 56.78 61.32 53.18
Only index persons 53.25 57.24 50.34

-FinnGen-

Key figures

All Female Male
Number of individuals 2441 1014 1427
Unadjusted period prevalence (%) 0.58 0.40 0.72
Median age at first event (years) 54.85 52.63 56.42

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint M13_PYOGARTH and mortality.

Females

Parameter HR [95% CI] p-value
M13_PYOGARTH 1.772 [1.59, 1.97] < 0.001
Birth year 0.995 [0.99, 1.0] 0.213

During the follow-up period (1.1.1998 — 31.12.2019), 2437 out of 6682 females with M13_PYOGARTH died.

Males

Parameter HR [95% CI] p-value
M13_PYOGARTH 1.69 [1.53, 1.87] < 0.001
Birth year 0.989 [0.98, 1.0] 0.013

During the follow-up period (1.1.1998 — 31.12.2019), 2888 out of 9211 males with M13_PYOGARTH died.

Mortality risk

Mortality risk for people of age

years, who have M13_PYOGARTH.

N-year risk Females Males
1 0.193% 0.236%
5 0.992% 1.737%
10 2.648% 4.76%
15 4.869% 9.092%
20 8.508% 15.39%

Relationships between endpoints

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Index endpoint: M13_PYOGARTH – Pyogenic arthritis

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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