obsolete_juvenile idiopathic arthritis: ['A group of chronic, inflammatory childhood disorders of unknown etiology that primarily involve joints.']
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
36941 |
4. Check minimum number of eventsNone |
36941 |
5. Include endpoints |
40477 |
6. Filter based on genotype QC (FinnGen only) |
39202 |
Control definitions (FinnGen only)
Control exclude
M13_ARTHROPATHIES
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Polyarthropathies
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 332852 | 174929 | 154881 |
| Only index persons | 269866 | 144351 | 125515 |
| Unadjusted period prevalence (%) | |||
| Whole population | 4.68 | 5.01 | 4.33 |
| Only index persons | 5.07 | 5.31 | 4.79 |
| Median age at first event (years) | |||
| Whole population | 57.45 | 56.52 | 58.39 |
| Only index persons | 55.54 | 54.28 | 56.98 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 39202 | 21007 | 18195 |
| Unadjusted period prevalence (%) | 8.66 | 8.25 | 9.14 |
| Median age at first event (years) | 55.23 | 51.46 | 59.59 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_POLYARTHROPATHIES and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_POLYARTHROPATHIES | 1.607 [1.48, 1.75] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.154 |
During the follow-up period (1.1.1998 — 31.12.2019), 26072 out of 112164 females with M13_POLYARTHROPATHIES died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_POLYARTHROPATHIES | 1.708 [1.56, 1.87] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 27991 out of 100162 males with M13_POLYARTHROPATHIES died.
Mortality risk
Mortality risk for people of age
years, who have M13_POLYARTHROPATHIES.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.123% | 0.246% |
| 5 | 0.795% | 1.616% |
| 10 | 1.917% | 4.155% |
| 15 | 4.023% | 8.028% |
| 20 | 7.074% | 13.832% |
Relationships between endpoints
↥Index endpoint: M13_POLYARTHROPATHIES – Polyarthropathies
GWS hits: 18
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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