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Rheumatoid arthritis

DOID EFO Endpoint Browser PheWeb

M13_RHEUMA

rheumatoid arthritis: A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M05, M06
  • Hospital discharge: ICD-9 — 7140A|7140B|7241|7142
  • Hospital discharge: ICD-8 — 712[1-3]
  • Cause of death: ICD-10 — M05, M06
  • Cause of death: ICD-9 — 7140A|7140B|7241|7142
  • Cause of death: ICD-8 — 712[1-3]

2 out of 7 registries used, show all original rules.

15225

4. Check minimum number of events

None

15225

5. Include endpoints

None

15225

6. Filter based on genotype QC (FinnGen only)

14818

Control definitions (FinnGen only)

Control exclude M13_ARTHROPATHIES

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Rheumatoid arthritis based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 122129 82772 38172
Only index persons 94097 65400 28697
Unadjusted period prevalence (%)
Whole population 1.95 2.37 1.07
Only index persons 2.01 2.40 1.10
Median age at first event (years)
Whole population 56.51 56.02 57.52
Only index persons 54.66 54.03 56.10

-FinnGen-

Key figures

All Female Male
Number of individuals 14818 10029 4789
Unadjusted period prevalence (%) 3.44 3.94 2.41
Median age at first event (years) 53.36 51.50 57.25

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint M13_RHEUMA and mortality.

Females

Parameter HR [95% CI] p-value
M13_RHEUMA 1.418 [1.32, 1.52] < 0.001
Birth year 0.995 [0.99, 1.0] 0.206

During the follow-up period (1.1.1998 — 31.12.2019), 10109 out of 46537 females with M13_RHEUMA died.

Males

Parameter HR [95% CI] p-value
M13_RHEUMA 1.373 [1.27, 1.48] < 0.001
Birth year 0.989 [0.98, 1.0] 0.014

During the follow-up period (1.1.1998 — 31.12.2019), 6422 out of 22383 males with M13_RHEUMA died.

Mortality risk

Mortality risk for people of age

years, who have M13_RHEUMA.

N-year risk Females Males
1 0.11% 0.297%
5 0.8% 1.895%
10 2.12% 4.466%
15 3.984% 8.126%
20 6.711% 13.541%

Relationships between endpoints

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Index endpoint: M13_RHEUMA – Rheumatoid arthritis

GWS hits: 25

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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