adult-onset Still's disease: adult-onset Still disease (AOSD) is a rare inflammatory multisystem disorder characterized clinically by fever of unknown origin, arthralgia or arthritis, hyperleucocytosis, and typical skin rash.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
142 |
4. Check minimum number of eventsNone |
142 |
5. Include endpointsNone |
142 |
6. Filter based on genotype QC (FinnGen only) |
134 |
Control definitions (FinnGen only)
Control exclude
ILD_SYST_AUTO_DISEASES
Extra metadata
First used in FinnGen datafreeze
DF5
Parent code in ICD-10
M06
Name in latin
Arthritis rheumatoides seronegativa
Similar endpoints
↥List of similar endpoints to
Adult-onset Still disease
based on the number of shared cases.
Similar with more cases:
- Other (seronegative) rheumatoid arthritis, wide
- Rheumatoid arthritis
- Rheumatoid arthritis , including avohilmo
- Polyarthropathies
- Autoimmune diseases related-to ILD
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 695 | 385 | 303 |
| Only index persons | 637 | 353 | 284 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 49.30 | 49.81 | 48.68 |
| Only index persons | 47.00 | 47.43 | 46.47 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 134 | 83 | 51 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | 46.09 | 43.78 | 49.85 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint STILL_ADULT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| STILL_ADULT | 1.988 [1.4, 2.83] | < 0.001 |
| Birth year | 0.999 [0.99, 1.01] | 0.737 |
During the follow-up period (1.1.1998 — 31.12.2019), 53 out of 328 females with STILL_ADULT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| STILL_ADULT | 1.642 [1.18, 2.28] | 0.003 |
| Birth year | 0.988 [0.98, 1.0] | 0.009 |
During the follow-up period (1.1.1998 — 31.12.2019), 57 out of 253 males with STILL_ADULT died.
Mortality risk
Mortality risk for people of age
years, who have STILL_ADULT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.161% | 0.335% |
| 5 | 1.301% | 1.57% |
| 10 | 3.268% | 4.225% |
| 15 | 6.061% | 8.388% |
| 20 | 10.759% | 14.54% |
Relationships between endpoints
↥Index endpoint: STILL_ADULT – Adult-onset Still disease
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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