rheumatoid arthritis: A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
7511 |
4. Check minimum number of eventsNone |
7511 |
5. Include endpointsNone |
7511 |
6. Filter based on genotype QC (FinnGen only) |
7314 |
Control definitions (FinnGen only)
Control exclude
STILL_ADULT
Extra metadata
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M05-M14
Name in latin
Alia arthritis rheumatoides
Similar endpoints
↥List of similar endpoints to
Other (seronegative) rheumatoid arthritis, wide
based on the number of shared cases.
Similar with more cases:
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 60222 | 41926 | 17806 |
| Only index persons | 48566 | 34272 | 14294 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.99 | 1.20 | 0.50 |
| Only index persons | 1.05 | 1.26 | 0.55 |
| Median age at first event (years) | |||
| Whole population | 63.04 | 62.92 | 63.16 |
| Only index persons | 59.79 | 59.42 | 60.66 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 7314 | 5011 | 2303 |
| Unadjusted period prevalence (%) | 1.71 | 1.97 | 1.16 |
| Median age at first event (years) | 56.32 | 54.11 | 61.14 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint RHEUMA_OTHER_WIDE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| RHEUMA_OTHER_WIDE | 1.76 [1.63, 1.9] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.06 |
During the follow-up period (1.1.1998 — 31.12.2019), 8612 out of 28983 females with RHEUMA_OTHER_WIDE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| RHEUMA_OTHER_WIDE | 1.598 [1.46, 1.75] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 4267 out of 12686 males with RHEUMA_OTHER_WIDE died.
Mortality risk
Mortality risk for people of age
years, who have RHEUMA_OTHER_WIDE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.142% | 0.289% |
| 5 | 0.846% | 1.917% |
| 10 | 2.152% | 4.622% |
| 15 | 4.269% | 8.374% |
| 20 | 7.666% | 14.121% |
Relationships between endpoints
↥Index endpoint: RHEUMA_OTHER_WIDE – Other (seronegative) rheumatoid arthritis, wide
GWS hits: 5
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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