rheumatoid arthritis: A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
4686 |
4. Check minimum number of eventsNone |
4686 |
5. Include endpointsNone |
4686 |
6. Filter based on genotype QC (FinnGen only) |
4567 |
Control definitions (FinnGen only)
Control exclude
RHEUMA_ENDPOINTS
Extra metadata
First used in FinnGen datafreeze
DF3
Parent code in ICD-10
M06
Name in latin
Arthritis rheumatoides seronegativa
Similar endpoints
↥List of similar endpoints to
Seronegative rheumatoid arthritis
based on the number of shared cases.
Similar with more cases:
- Other (seronegative) rheumatoid arthritis, wide
- Rheumatoid arthritis
- Rheumatoid arthritis , including avohilmo
- Polyarthropathies
- Finngen Rheumatological endpoints
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 32653 | 23007 | 9442 |
| Only index persons | 27640 | 19750 | 7890 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.54 | 0.66 | 0.26 |
| Only index persons | 0.60 | 0.73 | 0.30 |
| Median age at first event (years) | |||
| Whole population | 58.77 | 58.03 | 60.42 |
| Only index persons | 56.74 | 56.04 | 58.50 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 4567 | 3237 | 1330 |
| Unadjusted period prevalence (%) | 1.10 | 1.27 | 0.67 |
| Median age at first event (years) | 54.93 | 53.18 | 59.17 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint RHEUMA_SERONEG and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| RHEUMA_SERONEG | 1.344 [1.24, 1.45] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.078 |
During the follow-up period (1.1.1998 — 31.12.2019), 3367 out of 15826 females with RHEUMA_SERONEG died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| RHEUMA_SERONEG | 1.235 [1.13, 1.35] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 1862 out of 6759 males with RHEUMA_SERONEG died.
Mortality risk
Mortality risk for people of age
years, who have RHEUMA_SERONEG.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.112% | 0.21% |
| 5 | 0.733% | 1.35% |
| 10 | 1.794% | 3.447% |
| 15 | 3.49% | 6.677% |
| 20 | 6.319% | 11.123% |
Relationships between endpoints
↥Index endpoint: RHEUMA_SERONEG – Seronegative rheumatoid arthritis
GWS hits: 4
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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