Felty's syndrome: Felty syndrome (FS), also known as ''super rheumatoid'' disease, is a severe form of rheumatoid arthritis (RA), characterized by a triad of RA, splenomegaly and neutropenia, resulting in susceptibility to bacterial infections.
Seropositive rheumatoid arthritis, strict definition
DOID EFO Endpoint Browser PheWeb
RHEUMA_SEROPOS_STRICT
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditions
|
10701 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
5569 |
4. Check minimum number of eventsNone |
5569 |
5. Include endpointsNone |
5569 |
6. Filter based on genotype QC (FinnGen only) |
5426 |
Control definitions (FinnGen only)
Control conditions
not RHEUMA_SEROPOS_OTH_ICD10
Extra metadata
First used in FinnGen datafreeze
DF3
Similar endpoints
↥List of similar endpoints to
Seropositive rheumatoid arthritis, strict definition
based on the number of shared cases.
Similar with more cases:
- Other/unspecified seropositive rheumatoid arthritis (ICD-10)
- Other/unspecified seropositive rheumatoid arthritis
- Seropositive rheumatoid arthritis, wide
- Seropositive rheumatoid arthritis
- Rheumatoid arthritis
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 31325 | 21200 | 9976 |
| Only index persons | 29603 | 20324 | 9279 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.50 | 0.61 | 0.28 |
| Only index persons | 0.62 | 0.75 | 0.35 |
| Median age at first event (years) | |||
| Whole population | 59.60 | 59.01 | 60.86 |
| Only index persons | 59.06 | 58.50 | 60.29 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 5426 | 3764 | 1662 |
| Unadjusted period prevalence (%) | 1.28 | 1.48 | 0.83 |
| Median age at first event (years) | 56.76 | 55.05 | 60.62 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint RHEUMA_SEROPOS_STRICT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| RHEUMA_SEROPOS_STRICT | 1.267 [1.16, 1.38] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.474 |
During the follow-up period (1.1.1998 — 31.12.2019), 2802 out of 18091 females with RHEUMA_SEROPOS_STRICT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| RHEUMA_SEROPOS_STRICT | 1.387 [1.26, 1.52] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 2121 out of 8553 males with RHEUMA_SEROPOS_STRICT died.
Mortality risk
Mortality risk for people of age
years, who have RHEUMA_SEROPOS_STRICT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.099% | 0.247% |
| 5 | 0.74% | 1.452% |
| 10 | 2.046% | 3.767% |
| 15 | 3.95% | 7.307% |
| 20 | 6.912% | 12.196% |
Relationships between endpoints
↥Index endpoint: RHEUMA_SEROPOS_STRICT – Seropositive rheumatoid arthritis, strict definition
GWS hits: 15
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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