rheumatoid arthritis: A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
11093 |
4. Check minimum number of eventsNone |
11093 |
5. Include endpointsNone |
11093 |
6. Filter based on genotype QC (FinnGen only) |
10814 |
Control definitions (FinnGen only)
Control exclude
RHEUMA_SEROPOS
Extra metadata
First used in FinnGen datafreeze
DF3
Parent code in ICD-10
M05-M14
Name in latin
Arthritis rheumatoides seropositiva
Seropositive rheumatoid arthritis, wide
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 85545 | 59182 | 25538 |
| Only index persons | 66718 | 47387 | 19331 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.39 | 1.70 | 0.71 |
| Only index persons | 1.45 | 1.74 | 0.74 |
| Median age at first event (years) | |||
| Whole population | 60.05 | 59.77 | 60.55 |
| Only index persons | 57.21 | 56.88 | 58.01 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 10814 | 7441 | 3373 |
| Unadjusted period prevalence (%) | 2.54 | 2.92 | 1.69 |
| Median age at first event (years) | 55.09 | 53.22 | 59.20 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint RHEUMA_SEROPOS_WIDE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| RHEUMA_SEROPOS_WIDE | 1.423 [1.33, 1.53] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.204 |
During the follow-up period (1.1.1998 — 31.12.2019), 8606 out of 36551 females with RHEUMA_SEROPOS_WIDE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| RHEUMA_SEROPOS_WIDE | 1.506 [1.4, 1.62] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 5115 out of 16462 males with RHEUMA_SEROPOS_WIDE died.
Mortality risk
Mortality risk for people of age
years, who have RHEUMA_SEROPOS_WIDE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.104% | 0.299% |
| 5 | 0.781% | 1.776% |
| 10 | 2.089% | 4.423% |
| 15 | 3.909% | 8.369% |
| 20 | 6.984% | 14.014% |
Relationships between endpoints
↥Index endpoint: RHEUMA_SEROPOS_WIDE – Seropositive rheumatoid arthritis, wide
GWS hits: 35
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data