rheumatoid arthritis: A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor.
Other/unspecified seropositive rheumatoid arthritis
DOID EFO Endpoint Browser PheWeb
RHEUMA_SEROPOS_OTH
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
10961 |
4. Check minimum number of eventsNone |
10961 |
5. Include endpointsNone |
10961 |
6. Filter based on genotype QC (FinnGen only) |
10688 |
Control definitions (FinnGen only)
Control exclude
RHEUMA_SEROPOS
Extra metadata
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other/unspecified seropositive rheumatoid arthritis
based on the number of shared cases.
Similar with more cases:
- Seropositive rheumatoid arthritis, wide
- Seropositive rheumatoid arthritis
- Rheumatoid arthritis
- Rheumatoid arthritis , including avohilmo
- Polyarthropathies
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 84300 | 58425 | 25065 |
| Only index persons | 65706 | 46757 | 18949 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.38 | 1.67 | 0.70 |
| Only index persons | 1.43 | 1.72 | 0.72 |
| Median age at first event (years) | |||
| Whole population | 60.02 | 59.71 | 60.57 |
| Only index persons | 57.19 | 56.84 | 58.03 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 10688 | 7360 | 3328 |
| Unadjusted period prevalence (%) | 2.51 | 2.89 | 1.67 |
| Median age at first event (years) | 55.09 | 53.23 | 59.20 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint RHEUMA_SEROPOS_OTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| RHEUMA_SEROPOS_OTH | 1.412 [1.32, 1.51] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.143 |
During the follow-up period (1.1.1998 — 31.12.2019), 8402 out of 35945 females with RHEUMA_SEROPOS_OTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| RHEUMA_SEROPOS_OTH | 1.414 [1.31, 1.52] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.009 |
During the follow-up period (1.1.1998 — 31.12.2019), 4975 out of 16096 males with RHEUMA_SEROPOS_OTH died.
Mortality risk
Mortality risk for people of age
years, who have RHEUMA_SEROPOS_OTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.115% | 0.303% |
| 5 | 0.744% | 1.667% |
| 10 | 2.039% | 4.269% |
| 15 | 3.871% | 8.304% |
| 20 | 6.935% | 13.36% |
Relationships between endpoints
↥Index endpoint: RHEUMA_SEROPOS_OTH – Other/unspecified seropositive rheumatoid arthritis
GWS hits: 35
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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