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This is a non-core endpoint: only basic statistics are computed.

Kaschin-Beck disease

M13_KASHINBECK

skin disease: Any deviation from the normal structure or function of the skin or subcutaneous tissue that is manifested by a characteristic set of symptoms and signs.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M12.1
  • Cause of death: ICD-10 M12.1

2 out of 7 registries used, show all original rules.

25

4. Check minimum number of events

None

25

5. Include endpoints

None

25

6. Filter based on genotype QC (FinnGen only)

24

Control definitions (FinnGen only)

Control exclude M13_ARTHROPATHIES

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M12
Name in latin Morbus Kashin-Beck

Case counts by codes

FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 287 187 100
Only index persons 269 177 92
Unadjusted period prevalence (%)
Whole population 0.00 0.01 0.00
Only index persons 0.01 0.01 0.00
Median age at first event (years)
Whole population - 63.85 58.81
Only index persons 61.33 62.76 58.59

-FinnGen-

Key figures

All Female Male
Number of individuals 24 14 10
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 61.62 57.45 67.44

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

Mortality – FinRegistry

Association

Association between endpoint M13_KASHINBECK and mortality.

Females

Parameter HR [95% CI] p-value
M13_KASHINBECK 1.032 [0.79, 1.34] 0.813
Birth year 0.996 [0.99, 1.0] 0.336

During the follow-up period (1.1.1998 — 31.12.2019), 64 out of 186 females with M13_KASHINBECK died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have M13_KASHINBECK.

N-year risk Females Males
1 0.107% No data
5 0.616% No data
10 1.581% No data
15 2.881% No data
20 5.35% No data

Relationships between endpoints

Index endpoint: M13_KASHINBECK – Kaschin-Beck disease

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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