This is a non-core endpoint: only basic statistics are computed.
Kaschin-Beck disease
M13_KASHINBECK
skin disease: Any deviation from the normal structure or function of the skin or subcutaneous tissue that is manifested by a characteristic set of symptoms and signs.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
25 |
4. Check minimum number of eventsNone |
25 |
5. Include endpointsNone |
25 |
6. Filter based on genotype QC (FinnGen only) |
24 |
Control definitions (FinnGen only)
Control exclude
M13_ARTHROPATHIES
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M12
Name in latin
Morbus Kashin-Beck
Similar endpoints
↥List of similar endpoints to
Kaschin-Beck disease
based on the number of shared cases.
Similar with more cases:
- Polyarthropathies
- Arthropathies
- Diseases of the musculoskeletal system and connective tissue
- Anti-inflammatory and antirheumatic products, non-steroids
- Paracetamol of NSAID medication
Similar with less cases:
None
Case counts by codes
↥Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 287 | 187 | 100 |
| Only index persons | 269 | 177 | 92 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.00 | 0.01 | 0.00 |
| Only index persons | 0.01 | 0.01 | 0.00 |
| Median age at first event (years) | |||
| Whole population | - | 63.85 | 58.81 |
| Only index persons | 61.33 | 62.76 | 58.59 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 24 | 14 | 10 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | 61.62 | 57.45 | 67.44 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
Mortality – FinRegistry
↥Association
Association between endpoint M13_KASHINBECK and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_KASHINBECK | 1.032 [0.79, 1.34] | 0.813 |
| Birth year | 0.996 [0.99, 1.0] | 0.336 |
During the follow-up period (1.1.1998 — 31.12.2019), 64 out of 186 females with M13_KASHINBECK died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have M13_KASHINBECK.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.107% | No data |
| 5 | 0.616% | No data |
| 10 | 1.581% | No data |
| 15 | 2.881% | No data |
| 20 | 5.35% | No data |
Relationships between endpoints
↥Index endpoint: M13_KASHINBECK – Kaschin-Beck disease
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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