Paracetamol of NSAID medication

RX_PARACETAMOL_NSAID

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Medicine purchases: ATC N02BE01|N02BE51|M01A|M01B

1 out of 7 registries used, show all original rules.

397604

4. Check minimum number of events

Min. number of events 3
397604

5. Include endpoints

None

397604

6. Filter based on genotype QC (FinnGen only)

382510

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze DF5

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4047479 2165498 1856583
Only index persons 3785975 2043748 1742227
Unadjusted period prevalence (%)
Whole population 57.15 62.03 51.87
Only index persons 71.16 75.13 66.51
Median age at first event (years)
Whole population 40.07 40.98 38.98
Only index persons 38.64 39.56 37.57

-FinnGen-

Key figures

All Female Male
Number of individuals 382510 223516 158994
Unadjusted period prevalence (%) 84.49 87.78 79.85
Median age at first event (years) 40.47 37.59 44.51

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint RX_PARACETAMOL_NSAID and mortality.

Females

Parameter HR [95% CI] p-value
RX_PARACETAMOL_NSAID 0.8 [0.75, 0.85] < 0.001
Birth year 0.999 [0.99, 1.01] 0.755

During the follow-up period (1.1.1998 — 31.12.2019), 130281 out of 1353979 females with RX_PARACETAMOL_NSAID died.

Males

Parameter HR [95% CI] p-value
RX_PARACETAMOL_NSAID 0.791 [0.74, 0.84] < 0.001
Birth year 0.992 [0.98, 1.0] 0.03

During the follow-up period (1.1.1998 — 31.12.2019), 135553 out of 1250642 males with RX_PARACETAMOL_NSAID died.

Mortality risk

Mortality risk for people of age

years, who have RX_PARACETAMOL_NSAID.

N-year risk Females Males
1 0.081% 0.135%
5 0.456% 0.91%
10 1.139% 2.333%
15 2.228% 4.747%
20 4.104% 8.188%

Relationships between endpoints

Index endpoint: RX_PARACETAMOL_NSAID – Paracetamol of NSAID medication

GWS hits: 22

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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