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Juvenile rheumatoid arthirtis

DOID EFO Endpoint Browser PheWeb

M13_JUVERHEU

obsolete_juvenile idiopathic arthritis: ['A group of chronic, inflammatory childhood disorders of unknown etiology that primarily involve joints.']

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M08.0
  • Hospital discharge: ICD-9 — 7143A
  • Hospital discharge: ICD-8 — 7120
  • Cause of death: ICD-10 — M08.0
  • Cause of death: ICD-9 — 7143A
  • Cause of death: ICD-8 — 7120

2 out of 7 registries used, show all original rules.

846

4. Check minimum number of events

None

846

5. Include endpoints

None

846

6. Filter based on genotype QC (FinnGen only)

828

Control definitions (FinnGen only)

Control exclude M13_ARTHROPATHIES

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M08
Name in latin Arthritis rheumatoides juvenilis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 6871 4777 2076
Only index persons 6074 4261 1813
Unadjusted period prevalence (%)
Whole population 0.11 0.14 0.06
Only index persons 0.13 0.16 0.07
Median age at first event (years)
Whole population 14.63 15.17 13.09
Only index persons 14.11 14.74 12.62

-FinnGen-

Key figures

All Female Male
Number of individuals 828 644 184
Unadjusted period prevalence (%) 0.22 0.25 0.09
Median age at first event (years) 15.92 16.19 14.98

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint M13_JUVERHEU and mortality.

Females

Parameter HR [95% CI] p-value
M13_JUVERHEU 2.122 [1.71, 2.64] < 0.001
Birth year 0.994 [0.99, 1.0] 0.212

During the follow-up period (1.1.1998 — 31.12.2019), 134 out of 2356 females with M13_JUVERHEU died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have M13_JUVERHEU.

N-year risk Females Males
1 0.26% No data
5 1.389% No data
10 3.177% No data
15 6.134% No data
20 10.86% No data

Relationships between endpoints

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Index endpoint: M13_JUVERHEU – Juvenile rheumatoid arthirtis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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