No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
1853 |
6. Filter based on genotype QC (FinnGen only) |
1798 |
Control definitions (FinnGen only)
Control exclude
RHEUMA_ENDPOINTS
Extra metadata
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Juvenile arthritis (FINNGEN)
based on the number of shared cases.
Similar with more cases:
- Polyarthropathies
- Finngen Rheumatological endpoints
- Arthropathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 18285 | 11447 | 6796 |
| Only index persons | 15588 | 9823 | 5765 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.28 | 0.33 | 0.19 |
| Only index persons | 0.31 | 0.36 | 0.22 |
| Median age at first event (years) | |||
| Whole population | 11.91 | 12.32 | 10.93 |
| Only index persons | 12.10 | 12.59 | 11.28 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1798 | 1321 | 477 |
| Unadjusted period prevalence (%) | 0.44 | 0.52 | 0.24 |
| Median age at first event (years) | 14.36 | 14.24 | 14.68 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint JUVEN_ARTHR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| JUVEN_ARTHR | 2.325 [1.98, 2.74] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.155 |
During the follow-up period (1.1.1998 — 31.12.2019), 427 out of 7107 females with JUVEN_ARTHR died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| JUVEN_ARTHR | 2.434 [2.02, 2.94] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 319 out of 4521 males with JUVEN_ARTHR died.
Mortality risk
Mortality risk for people of age
years, who have JUVEN_ARTHR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.216% | 0.387% |
| 5 | 1.595% | 2.803% |
| 10 | 3.544% | 6.752% |
| 15 | 6.372% | 11.995% |
| 20 | 11.096% | 19.849% |
Relationships between endpoints
↥Index endpoint: JUVEN_ARTHR – Juvenile arthritis (FINNGEN)
GWS hits: 4
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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