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Monoarthritis, not elsewhere classified

DOID EFO Endpoint Browser PheWeb

M13_MONOARTHRITIS

arthritis: An inflammatory process affecting a joint. Causes include infection, autoimmune processes, degenerative processes, and trauma. Signs and symptoms may include swelling around the affected joint and pain.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M13.1
  • Hospital discharge: ICD-9 — 7166
  • Hospital discharge: ICD-8 — 711
  • Hospital discharge: excluded ICD-8 — 7110[8-9]
  • Cause of death: ICD-10 — M13.1
  • Cause of death: ICD-9 — 7166
  • Cause of death: ICD-8 — 711
  • Cause of death: excluded ICD-8 — 7110[8-9]

2 out of 7 registries used, show all original rules.

1592

4. Check minimum number of events

None

1592

5. Include endpoints

None

1592

6. Filter based on genotype QC (FinnGen only)

1553

Control definitions (FinnGen only)

Control exclude M13_ARTHROPATHIES

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M13
Name in latin Monoarthritis non alibi classificata

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 13581 7027 6469
Only index persons 11719 6178 5541
Unadjusted period prevalence (%)
Whole population 0.19 0.20 0.18
Only index persons 0.22 0.23 0.21
Median age at first event (years)
Whole population 42.99 45.65 39.95
Only index persons 40.21 43.14 36.95

-FinnGen-

Key figures

All Female Male
Number of individuals 1553 893 660
Unadjusted period prevalence (%) 0.34 0.35 0.33
Median age at first event (years) 44.64 41.88 48.37

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint M13_MONOARTHRITIS and mortality.

Females

Parameter HR [95% CI] p-value
M13_MONOARTHRITIS 1.23 [1.09, 1.39] < 0.001
Birth year 0.997 [0.99, 1.0] 0.419

During the follow-up period (1.1.1998 — 31.12.2019), 544 out of 3892 females with M13_MONOARTHRITIS died.

Males

Parameter HR [95% CI] p-value
M13_MONOARTHRITIS 1.29 [1.12, 1.48] < 0.001
Birth year 0.992 [0.98, 1.0] 0.151

During the follow-up period (1.1.1998 — 31.12.2019), 540 out of 3094 males with M13_MONOARTHRITIS died.

Mortality risk

Mortality risk for people of age

years, who have M13_MONOARTHRITIS.

N-year risk Females Males
1 0.127% 0.331%
5 0.767% 1.819%
10 1.901% 4.276%
15 3.597% 8.309%
20 6.664% 13.939%

Relationships between endpoints

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Index endpoint: M13_MONOARTHRITIS – Monoarthritis, not elsewhere classified

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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