arthritis: An inflammatory process affecting a joint. Causes include infection, autoimmune processes, degenerative processes, and trauma. Signs and symptoms may include swelling around the affected joint and pain.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
13836 |
6. Filter based on genotype QC (FinnGen only) |
13415 |
Control definitions (FinnGen only)
Control exclude
RHEUMA_ENDPOINTS
Extra metadata
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other arthritis (FG)
based on the number of shared cases.
Similar with more cases:
- Polyarthropathies
- Finngen Rheumatological endpoints
- Arthropathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 100819 | 55962 | 44410 |
| Only index persons | 92256 | 51916 | 40340 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.44 | 1.60 | 1.24 |
| Only index persons | 1.75 | 1.91 | 1.54 |
| Median age at first event (years) | |||
| Whole population | 51.30 | 51.19 | 51.39 |
| Only index persons | 50.81 | 50.60 | 51.08 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 13415 | 8073 | 5342 |
| Unadjusted period prevalence (%) | 2.98 | 3.17 | 2.68 |
| Median age at first event (years) | 52.82 | 49.96 | 57.13 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint RHEU_ARTHRITIS_OTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| RHEU_ARTHRITIS_OTH | 1.327 [1.22, 1.44] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.114 |
During the follow-up period (1.1.1998 — 31.12.2019), 6286 out of 43857 females with RHEU_ARTHRITIS_OTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| RHEU_ARTHRITIS_OTH | 1.444 [1.31, 1.59] | < 0.001 |
| Birth year | 0.984 [0.98, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 6470 out of 33491 males with RHEU_ARTHRITIS_OTH died.
Mortality risk
Mortality risk for people of age
years, who have RHEU_ARTHRITIS_OTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.131% | 0.259% |
| 5 | 0.729% | 1.506% |
| 10 | 1.947% | 3.459% |
| 15 | 3.651% | 6.768% |
| 20 | 6.204% | 11.586% |
Relationships between endpoints
↥Index endpoint: RHEU_ARTHRITIS_OTH – Other arthritis (FG)
GWS hits: 3
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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