No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
572 |
4. Check minimum number of eventsNone |
572 |
5. Include endpointsNone |
572 |
6. Filter based on genotype QC (FinnGen only) |
548 |
Control definitions (FinnGen only)
Control exclude
M13_ARTHROPATHIES
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M05-M14
Name in latin
Aliae arthropathiae crystallinae
Similar endpoints
↥List of similar endpoints to
Other crystal arthropathies
based on the number of shared cases.
Similar with more cases:
- Crystal arthropathies, rheuma endpoint
- Polyarthropathies
- Finngen Rheumatological endpoints
- Arthropathies
- Diseases of the musculoskeletal system and connective tissue
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4483 | 2473 | 1985 |
| Only index persons | 3918 | 2148 | 1770 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.07 | 0.06 |
| Only index persons | 0.07 | 0.08 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 74.22 | 76.55 | 71.34 |
| Only index persons | 73.90 | 76.25 | 71.05 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 548 | 266 | 282 |
| Unadjusted period prevalence (%) | 0.12 | 0.10 | 0.14 |
| Median age at first event (years) | 71.44 | 71.06 | 71.80 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_CRYSTALARTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_CRYSTALARTH | 1.431 [1.21, 1.69] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.367 |
During the follow-up period (1.1.1998 — 31.12.2019), 770 out of 1835 females with M13_CRYSTALARTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_CRYSTALARTH | 1.52 [1.24, 1.86] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.008 |
During the follow-up period (1.1.1998 — 31.12.2019), 558 out of 1418 males with M13_CRYSTALARTH died.
Mortality risk
Mortality risk for people of age
years, who have M13_CRYSTALARTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.12% | 0.257% |
| 5 | 0.769% | 1.859% |
| 10 | 2.002% | 4.559% |
| 15 | 4.112% | 8.323% |
| 20 | 7.602% | 14.276% |
Relationships between endpoints
↥Index endpoint: M13_CRYSTALARTH – Other crystal arthropathies
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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