No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
178 |
4. Check minimum number of eventsNone |
178 |
5. Include endpointsNone |
178 |
6. Filter based on genotype QC (FinnGen only) |
169 |
Control definitions (FinnGen only)
Control exclude
RHEUMA_CHRYSTAL
Extra metadata
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other/unspecified crystal arthropathies
based on the number of shared cases.
Similar with more cases:
- Other crystal arthropathies
- Crystal arthropathies, rheuma endpoint
- Polyarthropathies
- Finngen Rheumatological endpoints
- Arthropathies
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1547 | 864 | 670 |
| Only index persons | 1294 | 716 | 578 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.03 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 73.60 | 75.80 | 70.78 |
| Only index persons | 72.74 | 74.85 | 70.12 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 169 | 89 | 80 |
| Unadjusted period prevalence (%) | 0.04 | 0.03 | 0.04 |
| Median age at first event (years) | 68.87 | 67.78 | 70.08 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint CHRYSTAL_NOS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CHRYSTAL_NOS | 1.612 [1.3, 2.0] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.049 |
During the follow-up period (1.1.1998 — 31.12.2019), 301 out of 641 females with CHRYSTAL_NOS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CHRYSTAL_NOS | 1.755 [1.31, 2.36] | < 0.001 |
| Birth year | 0.982 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 218 out of 482 males with CHRYSTAL_NOS died.
Mortality risk
Mortality risk for people of age
years, who have CHRYSTAL_NOS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.143% | 0.325% |
| 5 | 0.84% | 1.923% |
| 10 | 2.169% | 4.736% |
| 15 | 4.007% | 8.626% |
| 20 | 7.146% | 14.061% |
Relationships between endpoints
↥Index endpoint: CHRYSTAL_NOS – Other/unspecified crystal arthropathies
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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