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Gout

DOID EFO Endpoint Browser PheWeb

M13_GOUT

gout: A condition characterized by painful swelling of the joints, which is caused by deposition of urate crystals.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M10
  • Hospital discharge: ICD-9 — 2740
  • Hospital discharge: ICD-8 — 2740
  • Cause of death: ICD-10 — M10
  • Cause of death: ICD-9 — 2740
  • Cause of death: ICD-8 — 2740
  • KELA reimbursements: KELA codes — 212

3 out of 7 registries used, show all original rules.

11285

4. Check minimum number of events

None

11285

5. Include endpoints

None

11285

6. Filter based on genotype QC (FinnGen only)

10888

Control definitions (FinnGen only)

Control exclude M13_ARTHROPATHIES

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M05-M14

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 106476 34310 70743
Only index persons 80076 25035 55041
Unadjusted period prevalence (%)
Whole population 1.65 0.98 1.98
Only index persons 1.73 0.92 2.10
Median age at first event (years)
Whole population 69.14 75.51 66.10
Only index persons 68.92 75.83 65.77

-FinnGen-

Key figures

All Female Male
Number of individuals 10888 2648 8240
Unadjusted period prevalence (%) 3.38 1.04 4.14
Median age at first event (years) 67.06 69.99 66.11

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint M13_GOUT and mortality.

Females

Parameter HR [95% CI] p-value
M13_GOUT 2.217 [2.0, 2.46] < 0.001
Birth year 0.993 [0.99, 1.0] 0.088

During the follow-up period (1.1.1998 — 31.12.2019), 11540 out of 22477 females with M13_GOUT died.

Males

Parameter HR [95% CI] p-value
M13_GOUT 2.072 [1.86, 2.31] < 0.001
Birth year 0.985 [0.98, 0.99] 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 17217 out of 45017 males with M13_GOUT died.

Mortality risk

Mortality risk for people of age

years, who have M13_GOUT.

N-year risk Females Males
1 0.185% 0.328%
5 1.003% 2.263%
10 2.77% 5.535%
15 5.253% 10.185%
20 9.297% 16.467%

Relationships between endpoints

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Index endpoint: M13_GOUT – Gout

GWS hits: 16

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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