gout: A condition characterized by painful swelling of the joints, which is caused by deposition of urate crystals.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditions
|
8855 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
5995 |
4. Check minimum number of events
Min. number of events
3
|
5995 |
5. Include endpointsNone |
5995 |
6. Filter based on genotype QC (FinnGen only) |
5793 |
Control definitions (FinnGen only)
Control conditions
not GOUT_IDIOP_NOS
Extra metadata
First used in FinnGen datafreeze
DF3
Gout, strict definition
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 49278 | 14513 | 34493 |
| Only index persons | 44249 | 12661 | 31588 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.80 | 0.42 | 0.96 |
| Only index persons | 0.99 | 0.47 | 1.21 |
| Median age at first event (years) | |||
| Whole population | 66.54 | 74.20 | 63.27 |
| Only index persons | 65.57 | 73.23 | 62.49 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 5793 | 1231 | 4562 |
| Unadjusted period prevalence (%) | 1.91 | 0.48 | 2.29 |
| Median age at first event (years) | 62.87 | 67.09 | 61.73 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint GOUT_STRICT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| GOUT_STRICT | 1.403 [1.29, 1.52] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.115 |
During the follow-up period (1.1.1998 — 31.12.2019), 5765 out of 12022 females with GOUT_STRICT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| GOUT_STRICT | 1.279 [1.18, 1.39] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 9154 out of 27678 males with GOUT_STRICT died.
Mortality risk
Mortality risk for people of age
years, who have GOUT_STRICT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.158% | 0.27% |
| 5 | 0.797% | 1.356% |
| 10 | 1.88% | 3.243% |
| 15 | 3.648% | 6.38% |
| 20 | 6.454% | 11.063% |
Relationships between endpoints
↥Index endpoint: GOUT_STRICT – Gout, strict definition
GWS hits: 10
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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