gout: A condition characterized by painful swelling of the joints, which is caused by deposition of urate crystals.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
2936 |
4. Check minimum number of eventsNone |
2936 |
5. Include endpointsNone |
2936 |
6. Filter based on genotype QC (FinnGen only) |
2838 |
Control definitions (FinnGen only)
Control exclude
GOUT
Extra metadata
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M10
Name in latin
Arthritis urica idiopathica
Idiopathic gout
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 24455 | 6615 | 17693 |
| Only index persons | 21996 | 5824 | 16172 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.41 | 0.19 | 0.49 |
| Only index persons | 0.51 | 0.21 | 0.62 |
| Median age at first event (years) | |||
| Whole population | 70.11 | 77.39 | 67.37 |
| Only index persons | 69.50 | 76.90 | 66.83 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2838 | 606 | 2232 |
| Unadjusted period prevalence (%) | 0.93 | 0.24 | 1.12 |
| Median age at first event (years) | 68.35 | 71.08 | 67.61 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint GOUT_IDIO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| GOUT_IDIO | 2.162 [1.9, 2.46] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.25 |
During the follow-up period (1.1.1998 — 31.12.2019), 2832 out of 5476 females with GOUT_IDIO died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| GOUT_IDIO | 2.057 [1.84, 2.3] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.008 |
During the follow-up period (1.1.1998 — 31.12.2019), 5557 out of 14710 males with GOUT_IDIO died.
Mortality risk
Mortality risk for people of age
years, who have GOUT_IDIO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.256% | 0.508% |
| 5 | 1.421% | 2.605% |
| 10 | 3.318% | 6.247% |
| 15 | 5.785% | 11.438% |
| 20 | 10.119% | 18.54% |
Relationships between endpoints
↥Index endpoint: GOUT_IDIO – Idiopathic gout
GWS hits: 3
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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