gout: A condition characterized by painful swelling of the joints, which is caused by deposition of urate crystals.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
7123 |
4. Check minimum number of eventsNone |
7123 |
5. Include endpointsNone |
7123 |
6. Filter based on genotype QC (FinnGen only) |
6872 |
Control definitions (FinnGen only)
Control exclude
GOUT
Extra metadata
First used in FinnGen datafreeze
DF2
Gout, unspecified
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 58180 | 18602 | 39261 |
| Only index persons | 52030 | 16202 | 35828 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.91 | 0.53 | 1.10 |
| Only index persons | 1.13 | 0.60 | 1.37 |
| Median age at first event (years) | |||
| Whole population | 72.33 | 78.73 | 69.28 |
| Only index persons | 71.69 | 78.17 | 68.75 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 6872 | 1629 | 5243 |
| Unadjusted period prevalence (%) | 2.16 | 0.64 | 2.63 |
| Median age at first event (years) | 69.67 | 71.68 | 69.04 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint GOUT_NOS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| GOUT_NOS | 2.125 [1.9, 2.38] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.161 |
During the follow-up period (1.1.1998 — 31.12.2019), 7951 out of 15425 females with GOUT_NOS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| GOUT_NOS | 2.233 [1.98, 2.52] | < 0.001 |
| Birth year | 0.984 [0.98, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 12429 out of 32414 males with GOUT_NOS died.
Mortality risk
Mortality risk for people of age
years, who have GOUT_NOS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.153% | 0.374% |
| 5 | 1.165% | 1.976% |
| 10 | 3.047% | 5.16% |
| 15 | 5.725% | 9.978% |
| 20 | 10.141% | 16.415% |
Relationships between endpoints
↥Index endpoint: GOUT_NOS – Gout, unspecified
GWS hits: 10
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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